Facile synthesis of an up-conversion luminescent and mesoporous Gd(2)O(3):Er(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier
文献类型：期刊论文
| 作者 | Xu ZH ; Li CX ; Ma PA ; Hou ZY ; Yang DM ; Kang XJ ; Lin J |
| 刊名 | nanoscale
 |
| 出版日期 | 2011 |
| 卷号 | 3期号:2页码:661-667 |
| 关键词 | SOL-GEL APPROACH WHITE-LIGHT CONTROLLED-RELEASE ENERGY-TRANSFER IN-VITRO NANOPARTICLES DELIVERY NANOCRYSTALS SILICA SYSTEM |
| ISSN号 | 2040-3364 |
| 通讯作者 | ma pa |
| 中文摘要 | in this paper, we report the facile synthesis of a bifunctional inorganic nanocomposite which is composed of core-shell structured mesoporous silica coated with up-conversion gd(2)o(3) : er(3+) particles. x-ray diffraction (xrd), scanning electron microscopy (sem), transmission electron microscopy (tem), n(2) adsorption/desorption, and photoluminescence (pl) spectra were used to characterize the samples. the results indicate that the nanocomposite with general 50 nm shell thickness and 300 nm core size shows typical ordered mesoporous characteristics (2.3 nm) and has spherical morphology with smooth surface and narrow size distribution. the bifunctional system shows unique green up-conversion emission under 980 nm nir laser excitation even after loading with drug molecules. in addition, biocompatibility tests on l929 fibroblast cells using an mtt assay reveals low cytotoxicity of the system. drug release tests suggest that the nanocomposite has a controlled drug release property with ibuprofen (ibu) as the model drug. interestingly, the up-conversion emission intensity of the bifunctional carrier increases with the released amount of model drug, thus allowing the release process to be monitored and tracked by the change of up-conversion luminescence intensity. this composite can potentially act as a functional drug carrier system. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2012-06-12 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/45051]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu ZH,Li CX,Ma PA,et al. Facile synthesis of an up-conversion luminescent and mesoporous Gd(2)O(3):Er(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier[J]. nanoscale,2011,3(2):661-667. |
| APA | Xu ZH.,Li CX.,Ma PA.,Hou ZY.,Yang DM.,...&Lin J.(2011).Facile synthesis of an up-conversion luminescent and mesoporous Gd(2)O(3):Er(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier.nanoscale,3(2),661-667. |
| MLA | Xu ZH,et al."Facile synthesis of an up-conversion luminescent and mesoporous Gd(2)O(3):Er(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier".nanoscale 3.2(2011):661-667. |
入库方式： OAI收割
来源：长春应用化学研究所
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