Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus
文献类型：期刊论文
| 作者 | Wang, Lei1,2 ; He, Hong-Ping1; Di, Ying-Tong1; Zhang, Yu1; Hao, Xiao-Jiang1
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2012-03-28 |
| 卷号 | 53期号:13页码:1576-1578 |
| 关键词 | Catharoseumine Monoterpenoid indole alkaloid Perxoxy bridge Catharanthus roseus |
| ISSN号 | 0040-4039 |
| 通讯作者 | Zhang, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China, zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn |
| 英文摘要 | Catharoseumine (1), a new monoterpenoid indole alkaloid possessing a unique peroxy bridge moiety, was isolated from the whole plants of Catharanthus roseus. Its structure was elucidated on the basis of NMR, IR, UV, and high-resolution mass spectrometric data, and its absolute configuration was determined by ECD and chemical methods. Catharoseumine (1) exhibited cytotoxicity against HL-60 cell line with IC50 value of 6.28 mu M and potential inhibition against Plasmodium falciparum falcipain-2 (IC50= 4.06 mu M). A plausible biogenetic pathway of 1 was also proposed. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | VINCA ALKALOIDS ; PATHWAY |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Funding of China[30830114, 31100259]; Ministry of Science and Technology[2009CB522300, 2009CB940900]; Young Academic and Technical Leader Raising Foundation of Yunnan Province[2009CI072]; HPC Center of Kunming Institute of Botany (KIB), Chinese Academy of Sciences (CAS) |
| 语种 | 英语 |
| WOS记录号 | WOS:000301692400011 |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/10433]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lei,He, Hong-Ping,Di, Ying-Tong,et al. Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus[J]. TETRAHEDRON LETTERS,2012,53(13):1576-1578. |
| APA | Wang, Lei,He, Hong-Ping,Di, Ying-Tong,Zhang, Yu,&Hao, Xiao-Jiang.(2012).Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus.TETRAHEDRON LETTERS,53(13),1576-1578. |
| MLA | Wang, Lei,et al."Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus".TETRAHEDRON LETTERS 53.13(2012):1576-1578. |
入库方式： OAI收割
来源：昆明植物研究所
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