Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide
文献类型：期刊论文
| 作者 | Xu, Junju1,2; Ji, Changjiu1; Zhang, Yumei1; Su, Jia1; Li, Yan1 ; Tan, Ninghua1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2012-02-15 |
| 卷号 | 22期号:4页码:1660-1663 |
| 关键词 | Zingiberaceae Alpinia oxyphylla Sesquiterpenes Oxyphyllanene A-G Inhibitory activity against NO production |
| ISSN号 | 0960-894X |
| 通讯作者 | Tan, NH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China, nhtan@mail.kib.ac.cn |
| 英文摘要 | Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Medicinal; Chemistry ; Organic |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | ABSOLUTE STEREOSTRUCTURES ; TEUCRIUM-HETEROPHYLLUM ; CHIRAL SYNTHON ; CHEMISTRY ; RHIZOMES ; THUJONE |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30725048, 31000159, 91013002, U1032602]; National Basic Research Program of China[2009CB522300]; Chinese Academy of Sciences[KSCX2-YW-R-177]; National New Drug Innovation Major Project of China[2011ZX09307-002-002] |
| 语种 | 英语 |
| WOS记录号 | WOS:000300404900035 |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/10449]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Junju,Ji, Changjiu,Zhang, Yumei,et al. Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(4):1660-1663. |
| APA | Xu, Junju,Ji, Changjiu,Zhang, Yumei,Su, Jia,Li, Yan,&Tan, Ninghua.(2012).Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(4),1660-1663. |
| MLA | Xu, Junju,et al."Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.4(2012):1660-1663. |
入库方式： OAI收割
来源：昆明植物研究所
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