Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
文献类型：期刊论文
| 作者 | Yang, Xiao-Dong1; Wan, Wei-Chao1; Deng, Xiao-Yan1; Li, Yan2 ; Yang, Li-Juan3,4; Li, Liang1; Zhang, Hong-Bin1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2012-04-15 |
| 卷号 | 22期号:8页码:2726-2729 |
| 关键词 | Hybrid compound Benzofuran Imidazole Cytotoxic activities Structure-activity relationships |
| ISSN号 | 0960-894X |
| 通讯作者 | Yang, XD (reprint author), Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China, xdyang@ynu.edu.cn ; liyanb@mail.kib.ac.cn |
| 英文摘要 | A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal; Chemistry, Organic |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | ANTITUMOR-ACTIVITY ; DERIVATIVES ; IODIDES ; ANALOGS ; TRANS |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30960460, 21062026, 2010GA014, 2009CB522300]; Yunnan Province; National Basic Research Program of China (973 Program) |
| 语种 | 英语 |
| WOS记录号 | WOS:000302768200016 |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/10451]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China 4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiao-Dong,Wan, Wei-Chao,Deng, Xiao-Yan,et al. Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(8):2726-2729. |
| APA | Yang, Xiao-Dong.,Wan, Wei-Chao.,Deng, Xiao-Yan.,Li, Yan.,Yang, Li-Juan.,...&Zhang, Hong-Bin.(2012).Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(8),2726-2729. |
| MLA | Yang, Xiao-Dong,et al."Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.8(2012):2726-2729. |
入库方式： OAI收割
来源：昆明植物研究所
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