单线态氧引起的蛋白质损伤研究
文献类型：期刊论文
| 作者 | 张兆霞,朱红平,葛敏,赵红卫,王文锋 |
| 刊名 | 辐射研究与辐射工艺学报
 |
| 出版日期 | 2005-04-30 |
| 期号 | 02 |
| 关键词 | 活性氧自由基 单线态氧 光敏剂 |
| 通讯作者 | 张兆霞 |
| 中文摘要 | Organisms produces reactive oxygen species (ROS) throughout their lives. ROS including superoxide anions, hydroxyl radicals, hydrogen peroxide and singlet oxygen whit known to oxidize biological macromolecules, The accumulation of oxidized, or modified, extra- and intra-cellular proteins in vivo cause age-related diseases such as Parkinson’s disease and cataract. Therefore, it is important to study the damage of proteins by photo-sensitizer. Singlet oxygen is a high reactive oxidant in biology systems, and that proteins are a major target for the damage initiated by this reactive species. Reaction with proteins occurs primarily at Trp, Met, Cys, His, and Tyr side-chains with this resulting in the formation of short-lived endo- or hydroperoxides on Trp, His, and Tyr resi- dues. This paper is a brief introduction about the reactions of singlet oxygen with tyrosine and histidine. |
| 收录类别 | CNKI |
| 公开日期 | 2012-07-04 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9276]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | 张兆霞,朱红平,葛敏,赵红卫,王文锋. 单线态氧引起的蛋白质损伤研究[J]. 辐射研究与辐射工艺学报,2005(02). |
| APA | 张兆霞,朱红平,葛敏,赵红卫,王文锋.(2005).单线态氧引起的蛋白质损伤研究.辐射研究与辐射工艺学报(02). |
| MLA | 张兆霞,朱红平,葛敏,赵红卫,王文锋."单线态氧引起的蛋白质损伤研究".辐射研究与辐射工艺学报 .02(2005). |
入库方式： OAI收割
来源：上海应用物理研究所
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