Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion
文献类型：期刊论文
| 作者 | Lei, Haozhi ; Mi, Lijuan（米丽娟） ; Zhou, Xuejiao ; Chen, Jiajia ; Hu, Jun（胡钧） ; Guo, Shouwu ; Zhang, Yi（张益） |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2011 |
| 卷号 | 3期号:9页码:3888 |
| ISSN号 | 2040-3364 |
| 英文摘要 | Investigation into the interactions between graphene oxide (GO) and biomolecules is very important for broad applications of GO in bioassay and bioanalysis. In this work, we describe the interactions between double-stranded DNA (dsDNA) and GO. We demonstrated that dsDNA can bind to GO forming complexes (dsDNA/GO) in the presence of certain salts, which protects dsDNA from being enzymatically digested. On the other hand, we found that a nonionic surfactant, such as triton X-100, can block the formation of dsDNA/GO complexes, so that the enzymatic digestion of dsDNA is restored. These results lead us to believe that the reason for GO protecting dsDNA from enzymatic digestion is the formation of dsDNA/GO complexes hindering the access of DNA enzymes to dsDNA, rather than direct inactivation of the DNA enzymes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294472600064 |
| 公开日期 | 2012-07-04 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9454]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Lei, Haozhi,Mi, Lijuan,Zhou, Xuejiao,et al. Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion[J]. NANOSCALE,2011,3(9):3888. |
| APA | Lei, Haozhi.,Mi, Lijuan.,Zhou, Xuejiao.,Chen, Jiajia.,Hu, Jun.,...&Zhang, Yi.(2011).Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion.NANOSCALE,3(9),3888. |
| MLA | Lei, Haozhi,et al."Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion".NANOSCALE 3.9(2011):3888. |
入库方式： OAI收割
来源：上海应用物理研究所
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