DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations
文献类型：期刊论文
| 作者 | Qi Wen-Peng(亓文鹏） ; Lei Xiao-Ling（雷晓玲） |
| 刊名 | CHINESE PHYSICS LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 28期号:4 |
| ISSN号 | 0256-307X |
| 英文摘要 | Investigating the interaction between protein and stretched DNA molecules has become a new way to study the protein DNA interaction. The conformations from different stretching methods give us a further understanding of the interaction between protein and DNA. We study the conformational variations of a 22-mer DNA caused by stretching both 3'- and 5'-termini by molecular dynamics simulations. It requires 250 kJ/mol to stretch the DNA molecule by 3'5'-termini for 3.5 nm and the force plateau is at 123.8 pN. The stretching 3'5'-termini leads to large values of the angle opening and the dihedral propeller between bases in one base pair, the double helix untwists from 34 degrees to 20 degrees and the successive base pairs rolls to the side of the DNA major groove. The distances between successive base pairs increases from 3.2 angstrom to 5.6 angstrom. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289195200066 |
| 公开日期 | 2012-07-04 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9494]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Qi Wen-Peng,Lei Xiao-Ling. DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations[J]. CHINESE PHYSICS LETTERS,2011,28(4). |
| APA | Qi Wen-Peng,&Lei Xiao-Ling.(2011).DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations.CHINESE PHYSICS LETTERS,28(4). |
| MLA | Qi Wen-Peng,et al."DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations".CHINESE PHYSICS LETTERS 28.4(2011). |
入库方式： OAI收割
来源：上海应用物理研究所
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