High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface
文献类型：期刊论文
| 作者 | Zhang, Yi（张益） ; Hu, Xiaofang ; Sun, Jielin ; Shen, Yi ; Hu, Jun（胡钧） ; Xu, Xuemin ; Shao, Zhifeng |
| 刊名 | MICROSCOPY RESEARCH AND TECHNIQUE
 |
| 出版日期 | 2011 |
| 卷号 | 74期号:7页码:614 |
| ISSN号 | 1059-910X |
| 英文摘要 | In this mini-review we discuss our recent findings on imaging and manipulation of biological macromolecular structures by atomic force microscopy (AFM). In the first part of this review, we focus on high-resolution imaging of selected biological samples. AFM images of membrane proteins have revealed detailed conformational features related to identifiable biological functions. Different self-assembling behaviors of short peptides into supramolecular structures on various substrates under controlled environmental conditions have been systematically studied with AFM imaging. In the second part, we present a novel nano-manipulation technique for manipulating, isolating, amplifying, and sequencing of individual DNA molecules, which may find unique applications in the analysis of difficult sequence structures. Finally, we discuss how to characterize the elasticity of individual biomolecules and live cells. These results demonstrate that not only the high resolution capacity of the AFM is suited to resolve certain biological questions, but can also be applied to single molecule isolation and biomechanical analysis with its unique advantages. Microsc. Res. Tech. 74: 614-626, 2011. (C) 2010 Wiley-Liss, Inc. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292570900006 |
| 公开日期 | 2012-07-04 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9519]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhang, Yi,Hu, Xiaofang,Sun, Jielin,et al. High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2011,74(7):614. |
| APA | Zhang, Yi.,Hu, Xiaofang.,Sun, Jielin.,Shen, Yi.,Hu, Jun.,...&Shao, Zhifeng.(2011).High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface.MICROSCOPY RESEARCH AND TECHNIQUE,74(7),614. |
| MLA | Zhang, Yi,et al."High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface".MICROSCOPY RESEARCH AND TECHNIQUE 74.7(2011):614. |
入库方式： OAI收割
来源：上海应用物理研究所
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