Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives
文献类型：期刊论文
| 作者 | Hata, Kuniki ; Lin, Mingzhang ; Katsumura, Yosuke ; Muroya, Yusa ; Fu, Haiying(付海英） ; Yamashita, Shinichi ; Nakagawa, Hidehiko |
| 刊名 | JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 52期号:1页码:15 |
| ISSN号 | 0449-3060 |
| 英文摘要 | A comparative study using the pulse radiolysis technique was carried out to investigate transient absorption spectra and rate constants for the reactions of (center dot)OH and N3(center dot) with edaravone (3-methyl-l-phenyl-2-pyrazolin-5-one) and its four analogue compounds, 1,3-dimethyl-2-pyrazolin-5-one, 3-methyl-1(pyridin-2-yl)-2-pyrazolin-5-one, 1-phenyl-3-trifluoromethyl-2-pyrazolin-5-one and 1-(4-chlorophenyl)-3methyl-2-pyrazolin-5-one. The results showed that, unlike reaction mechanisms previously proposed, the phenyl group of edaravone played an important role in the reaction with (center dot)OH and OH adducts to the phenyl group were formed. Quantum chemical calculations also strongly supported this attribution and suggested that the most favorable site for attacks by (center dot)OH is the anti position of the phenyl group. Moreover, the rate constants for the reactions of edaravone and its analogues towards (center dot)OH and N(3)(center dot) were about 8.0 x 10(9), and 4.0 x 10(9) dm(3) mol(-1) s(-1), respectively. Edaravone displayed higher reactivity compared to the others, in contrast to a previous report in which 3-methyl-1-(pyridin-2-yl)-2-pyrazolin-5-one showed the highest reactivity towards (center dot)OH. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287335400003 |
| 公开日期 | 2012-07-04 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9569]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Hata, Kuniki,Lin, Mingzhang,Katsumura, Yosuke,et al. Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives[J]. JOURNAL OF RADIATION RESEARCH,2011,52(1):15. |
| APA | Hata, Kuniki.,Lin, Mingzhang.,Katsumura, Yosuke.,Muroya, Yusa.,Fu, Haiying.,...&Nakagawa, Hidehiko.(2011).Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives.JOURNAL OF RADIATION RESEARCH,52(1),15. |
| MLA | Hata, Kuniki,et al."Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives".JOURNAL OF RADIATION RESEARCH 52.1(2011):15. |
入库方式： OAI收割
来源：上海应用物理研究所
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