Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
文献类型：期刊论文
| 作者 | Li, Ruibin1; Wu, Ren'an1; Zhao, Liang1; Hu, Zhengyan1; Guo, Shujing2; Pan, Xiulian2; Zou, Hanfa1 |
| 刊名 | carbon
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 49期号:5页码:1797-1805 |
| ISSN号 | 0008-6223 |
| 产权排序 | 1,1 |
| 通讯作者 | 吴仁安 |
| 中文摘要 | folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells |
| 英文摘要 | a nanomaterial, folate and iron difunctionalized multiwall carbon nanotube (fa-mwcnt@fe), has been synthesized by conjugating folate and iron nanoparticles with oxidized multi-walled carbon nanotubes, and applied as a dual-targeted drug nanocarrier to deliver doxorubicin into hela cells with the assistance of an external magnetic field. the prepared fa-mwcnt@fe was characterized by x-ray diffraction, transmission electron microscopy and infrared spectroscopy. this nanocarrier has a sufficient load capacity (doxorubicin/fa-mwcnt@fe, 32 mu g/mg) and a prolonged release property controlled by near infrared radiation. it also demonstrated both biologically (active) and magnetically (passive) targeting capabilities toward hela cells in vitro with ca. 6-fold higher delivery efficiency of doxorubicin than free doxorubicin. (c) 2011 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, physical ; materials science, multidisciplinary |
| 研究领域[WOS] | chemistry ; materials science |
| 关键词[WOS] | core-shell nanoparticles ; intracellular delivery ; controlled-release ; functionalization ; transporters ; design ; bioapplications ; doxorubicin ; discovery ; therapy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287952700034 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115190]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ruibin,Wu, Ren'an,Zhao, Liang,et al. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells[J]. carbon,2011,49(5):1797-1805. |
| APA | Li, Ruibin.,Wu, Ren'an.,Zhao, Liang.,Hu, Zhengyan.,Guo, Shujing.,...&Zou, Hanfa.(2011).Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells.carbon,49(5),1797-1805. |
| MLA | Li, Ruibin,et al."Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells".carbon 49.5(2011):1797-1805. |
入库方式： OAI收割
来源：大连化学物理研究所
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