Nanofiber-modified surface directed cell migration and orientation in microsystem
文献类型：期刊论文
| 作者 | Zhang, Xu1,2; Gao, Xinghua1,2; Jiang, Lei1; Zhang, Xulang1; Qin, Jianhua1 |
| 刊名 | biomicrofluidics
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 5期号:3页码:032007 |
| 关键词 | bioMEMS cellular biophysics electrospinning microfluidics nanobiotechnology nanofibres polymer fibres surface structure tissue engineering |
| ISSN号 | 待补充 |
| 产权排序 | 1,1 |
| 通讯作者 | 秦建华 |
| 中文摘要 | nanofiber-modified surface directed cell migration and orientation in microsystem |
| 英文摘要 | cell-microscale pattern surface interactions are crucial to understand many fundamental biological questions and develop regenerative medicine and tissue engineering approaches. in this work, we demonstrated a simple method to pattern pdms surface by sacrificing poly vinyl pyrrolidone (pvp) electrospinning nanofibers and investigated the growth profile of cells on the modified patterned surfaces using stroma cells. the stromal cells were observed to exhibit good viability on this modified surface and the patterned surface with alignment nanofibers could promote cell migration. furthermore, the modified pdms surface was integrated with microfluidic channels to create the microscale spatial factor and was used to explore the cell migration and orientation under this microsystem. both spatial factor and patterned surfaces were found to contribute to the complex cell orientation under the combined dual effects. this established method is simple, fast, and easy for use, demonstrating the potential of this microsystem for applications in addressing biological questions in complex environment. (c) 2011 american institute of physics. [doi:10.1063/1.3614457] |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; biophysics ; nanoscience & nanotechnology ; physics, fluids & plasmas |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics ; science & technology - other topics ; physics |
| 关键词[WOS] | dip-pen nanolithography ; patterns ; adhesion ; differentiation ; substrate ; protein ; fibers ; force |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295618500009 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115294]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xu,Gao, Xinghua,Jiang, Lei,et al. Nanofiber-modified surface directed cell migration and orientation in microsystem[J]. biomicrofluidics,2011,5(3):032007. |
| APA | Zhang, Xu,Gao, Xinghua,Jiang, Lei,Zhang, Xulang,&Qin, Jianhua.(2011).Nanofiber-modified surface directed cell migration and orientation in microsystem.biomicrofluidics,5(3),032007. |
| MLA | Zhang, Xu,et al."Nanofiber-modified surface directed cell migration and orientation in microsystem".biomicrofluidics 5.3(2011):032007. |
入库方式： OAI收割
来源：大连化学物理研究所
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