Metabonomic Study of Lung Cancer and the Effects of Radiotherapy on Lung Cancer Patients: Analysis of Highly Polar Metabolites by Ultraperformance HILIC Coupled with Q-TOF MS
文献类型：期刊论文
| 作者 | Cai, Xiaoming1; Dong, Jun1; Zou, Lijuan1,2; Xue, Xingya1; Zhang, Xiuli1; Liang, Xinmiao1 |
| 刊名 | chromatographia
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 74期号:5-6页码:391-398 |
| 关键词 | UPLC/Q-TOF Hydrophilic interaction chromatography Metabonomics Lung cancer Highly polar metabolites Radiotherapy |
| ISSN号 | 待补充 |
| 产权排序 | 1,1 |
| 通讯作者 | 张秀莉 ; 梁鑫淼 |
| 中文摘要 | metabonomic study of lung cancer and the effects of radiotherapy on lung cancer patients: analysis of highly polar metabolites by ultraperformance hilic coupled with q-tof ms |
| 英文摘要 | in this study, plasma samples were collected from 28 health volunteers and 66 lung cancer patients. ultraperformance hilic/q-tof ms-based metabonomic techniques were employed to compare the highly polar metabolites (hpms) in the plasma of patients with lung cancer and those in the plasma of healthy volunteers. high separation efficiency and good repeatability of the hilic/q-tof ms method were observed. partial least squares discriminant analysis (pls-da) of the data from both esi+ and esi- mode revealed good classifications between the health volunteer and the lung cancer patients. this result showed that the hpms from lung cancer patients and healthy controls were significantly different. the correct classification rate of models in both ion modes reached 100%, indicating that the metabonomics method established in this study could predict the plasma samples with high accuracy. besides, we found 19 ions that show a significant difference in levels between lung cancer patients and healthy controls. finally, we conducted a primary study of the effect of radiotherapy on hpms in lung cancer patients. clear differences among the hpms of patients in different radiotherapy periods and significant changes in levels of the 19 ions after radiotherapy were noted. this demonstrated that radiotherapy influences the metabolism system of patients. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | hydrophilic-interaction chromatography ; performance liquid-chromatography ; tandem mass-spectrometry ; rat urine ; zucker rat ; multivariate-analysis ; kidney cancer ; lc-ms/ms ; serum ; separation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294066000006 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115334]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China 2.Dalian Med Univ, Hosp 2, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Xiaoming,Dong, Jun,Zou, Lijuan,et al. Metabonomic Study of Lung Cancer and the Effects of Radiotherapy on Lung Cancer Patients: Analysis of Highly Polar Metabolites by Ultraperformance HILIC Coupled with Q-TOF MS[J]. chromatographia,2011,74(5-6):391-398. |
| APA | Cai, Xiaoming,Dong, Jun,Zou, Lijuan,Xue, Xingya,Zhang, Xiuli,&Liang, Xinmiao.(2011).Metabonomic Study of Lung Cancer and the Effects of Radiotherapy on Lung Cancer Patients: Analysis of Highly Polar Metabolites by Ultraperformance HILIC Coupled with Q-TOF MS.chromatographia,74(5-6),391-398. |
| MLA | Cai, Xiaoming,et al."Metabonomic Study of Lung Cancer and the Effects of Radiotherapy on Lung Cancer Patients: Analysis of Highly Polar Metabolites by Ultraperformance HILIC Coupled with Q-TOF MS".chromatographia 74.5-6(2011):391-398. |
入库方式： OAI收割
来源：大连化学物理研究所
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