Analysis of cephalosporins by hydrophilic interaction chromatography
文献类型：期刊论文
| 作者 | Liu, Qiaoxia1; Xu, Lingyan1; Ke, Yanxiong1; Jin, Yu1; Zhang, Feifang1; Liang, Xinmiao1,2 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2011-02-20 |
| 卷号 | 54期号:3页码:623-628 |
| 关键词 | Cephalosporins Hydrophilic interaction chromatography The Click beta-CD column Reversed-phase high performance liquid chromatography |
| ISSN号 | 待补充 |
| 产权排序 | 2,6 |
| 通讯作者 | 金郁 ; 章飞芳 |
| 中文摘要 | analysis of cephalosporins by hydrophilic interaction chromatography |
| 英文摘要 | a simple hydrophilic interaction chromatography (hilic) method was developed to analyze seven cephalosporins. these seven cephalosporins could be separated well on the click beta-cd column and atlantis hilic silica column. the effects of buffer concentration and ph on the retention under hilic mode were studied. except cefepime hydrochloride (4), the retention of other six cephalosporins increased with increasing buffer concentration, while decreased with increasing ph. different separation selectivities could be observed on the click beta-cd column and atlantis hilic silica column, and changing ph also resulted in the changing of separation selectivity. the separations of cephalosporins by hilic and reversed-phase high performance liquid chromatography (rp-hplc) were compared, and the two separation modes had good orthogonality. in addition, cefotaxime sodium (1) and its degradation were separated well on the click beta-cd column, which indicated that the click beta-cd column by hilic can be used for studying the stability of cephalosporins. (c) 2010 published by elsevier b.v. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | performance liquid-chromatography ; electrospray mass-spectrometry ; reversed-phase ; ion-exchange ; polar compounds ; drug discovery ; separation ; urine ; mode |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284814300033 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115356]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,et al. Analysis of cephalosporins by hydrophilic interaction chromatography[J]. journal of pharmaceutical and biomedical analysis,2011,54(3):623-628. |
| APA | Liu, Qiaoxia,Xu, Lingyan,Ke, Yanxiong,Jin, Yu,Zhang, Feifang,&Liang, Xinmiao.(2011).Analysis of cephalosporins by hydrophilic interaction chromatography.journal of pharmaceutical and biomedical analysis,54(3),623-628. |
| MLA | Liu, Qiaoxia,et al."Analysis of cephalosporins by hydrophilic interaction chromatography".journal of pharmaceutical and biomedical analysis 54.3(2011):623-628. |
入库方式： OAI收割
来源：大连化学物理研究所
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