The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4
文献类型：期刊论文
| 作者 | Dang, Yibing1; Li, Sheng1; Wang, Wenxia2; Wang, Shujing1; Zou, Mingming1; Guo, Yanjie1; Fan, Jianhui1; Du, Yuguang2; Zhang, Jianing1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2011-01-30 |
| 卷号 | 83期号:3页码:1075-1081 |
| 关键词 | Chitosan oligosaccharide Spleen dendritic cell TLR4 Immune response |
| ISSN号 | 0144-8617 |
| 产权排序 | 2,3 |
| 通讯作者 | 杜昱光 ; zhangjn |
| 中文摘要 | the effects of chitosan oligosaccharide on the activation of murine spleen cd11c(+) dendritic cells via toll-like receptor 4 |
| 英文摘要 | to investigate the effects of chitosan oligosaccharide (cos) on dendritic cells (dcs) and the role of toll-like receptor 4 (tlr4) in this immune process, murine spleen cd11c(+) dendritic cells (sdcs) were isolated and cultured with s-cos and b-cos with polymeration degree of 3-7 and 7-16, respectively. the results showed that 8-cos up-regulated the expressions of mhcii and cd86 on sdcs, promoted the secretion of tnf-alpha from sdcs. sdcs treated with b-cos stimulated the proliferation of the cd4(+)t cells. however, these effects were not observed on sdcs treated with s-cos. importantly, silencing the tlr4 expressions on sdcs by rna interference approach attenuated the expression of cd86, mhcii on sdcs, and the secretion of tnf-alpha from sdcs, and the stimulating cd4(+)t cells proliferation capacity of sdcs induced by b-cos. these results suggest that b-cos, but not s-cos, promotes the activation of sdcs and tlr4 plays a bridge role in this process. (c) 2010 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | rna interference ; ifn-gamma ; in-vivo ; delivery ; subsets ; mice ; oligochitosan ; maturation ; inhibit |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286965300005 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115522]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Dept Biochem, Inst Glycobiol, Dalian 116044, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dang, Yibing,Li, Sheng,Wang, Wenxia,et al. The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4[J]. carbohydrate polymers,2011,83(3):1075-1081. |
| APA | Dang, Yibing.,Li, Sheng.,Wang, Wenxia.,Wang, Shujing.,Zou, Mingming.,...&Zhang, Jianing.(2011).The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4.carbohydrate polymers,83(3),1075-1081. |
| MLA | Dang, Yibing,et al."The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via Toll-like receptor 4".carbohydrate polymers 83.3(2011):1075-1081. |
入库方式： OAI收割
来源：大连化学物理研究所
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