Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway
文献类型：期刊论文
| 作者 | Dou, Jiangli1,2; Ma, Pan1,2; Xiong, Chuannan1; Tan, Chengyu3; Du, Yuguang1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 86期号:1页码:19-24 |
| 关键词 | Oligochitosan HL-60 Bax/Bcl-2 Fas/FADD p21 Galectin-9 |
| ISSN号 | 0144-8617 |
| 产权排序 | 1,1 |
| 通讯作者 | 杜昱光 |
| 中文摘要 | induction of apoptosis in human acute leukemia hl-60 cells by oligochitosan through extrinsic and intrinsic pathway |
| 英文摘要 | the underlying cellular and molecular mechanism about oligochitosan induced hl-60 cell apoptosis remained unknown. in the present study, we found oligochitosan treated hl-60 cells showed enhanced cleavage of poly (adp-ribose) polymerase parp and p21 expression, accompanied with g0/g1 cell cycle arrest. after treatment with oligochitosan, the pro-apoptotic molecules fas. fadd and bax were up-regulated whereas anti-apoptotic bcl-2 expression in hl-60 cells was significantly decreased. furthermore, galectin-9 mrna expression was increased in the presence of oligochitosan. we thus over-expressed galectin-9s or galectin-9l and found galectin-9 could significantly increase the oligochitosan induced apoptotic rate of hl-60 cells. collectively, our data demonstrated that oligochitosan might regulate cell cycle progression and induce hl-60 cell apoptosis through both extrinsic and intrinsic pathways. (c) 2011 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | cycle arrest ; chitosan oligosaccharides ; dna-damage ; activation ; galectin-9 ; stress |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000293114900002 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115527]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Dalian 116023, Peoples R China 3.Dalian Ocean Univ, Coll Ocean Environm Engn, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dou, Jiangli,Ma, Pan,Xiong, Chuannan,et al. Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway[J]. carbohydrate polymers,2011,86(1):19-24. |
| APA | Dou, Jiangli,Ma, Pan,Xiong, Chuannan,Tan, Chengyu,&Du, Yuguang.(2011).Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway.carbohydrate polymers,86(1),19-24. |
| MLA | Dou, Jiangli,et al."Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway".carbohydrate polymers 86.1(2011):19-24. |
入库方式： OAI收割
来源：大连化学物理研究所
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