A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water
文献类型：期刊论文
| 作者 | Shan, Yuanhong; Shi, Xianzhe; Dou, Abo; Zou, Cunjie; He, Hongbing; Yang, Qin; Zhao, Sumin; Lu, Xin; Xu, Guowang |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 1218期号:13页码:1743-1748 |
| 关键词 | Microcystins Nodularin-R On-line micro solid-phase extraction Capillary liquid chromatography-mass spectrometry |
| ISSN号 | 待补充 |
| 产权排序 | 1,1 |
| 通讯作者 | 许国旺 |
| 中文摘要 | a fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-r in tap water and lake water |
| 英文摘要 | microcystins and nodularins are cyclic peptide hepatotoxins and tumour promoters from cyanobacteria. the present study describes the development, validation and practical application of a fully automated analytical method based on on-line micro solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry for the simultaneous determination of seven microcystins and nodularin-r in tap water and lake water. aliquots of just 100 mu l of water samples are sufficient for the detection and quantification of all eight toxins. selected reaction monitoring was used to obtain the highest sensitivity. good linear calibrations were obtained for microcystins (50-2000 ng/l) and nodularin-r (25-1000 ng/l) in spiked tap water and lake water samples. excellent interday and intraday repeatability were achieved for eight toxins with relative standard deviation less than 15.7% in three different concentrations. acceptable recoveries were achieved in the three concentrations with both tap water matrix and lake water matrix and no significant matrix effect was found in tap water and lake water except for microcystin-rr. the limits of detection (signal to noise ratio = 3) of toxins were lower than 56.6 ng/l which is far below the 1 mu g/l defined by the world health organization provisional guideline for microcystin-lr. finally, this method was successfully applied to lake water samples from tai lake and proved to be useful for water quality monitoring. (c) 2011 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | cyanobacterial toxins ; supplement products ; samples ; microextraction ; blooms ; lr |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288837400007 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115665]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shan, Yuanhong,Shi, Xianzhe,Dou, Abo,et al. A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water[J]. journal of chromatography a,2011,1218(13):1743-1748. |
| APA | Shan, Yuanhong.,Shi, Xianzhe.,Dou, Abo.,Zou, Cunjie.,He, Hongbing.,...&Xu, Guowang.(2011).A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water.journal of chromatography a,1218(13),1743-1748. |
| MLA | Shan, Yuanhong,et al."A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water".journal of chromatography a 1218.13(2011):1743-1748. |
入库方式： OAI收割
来源：大连化学物理研究所
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