Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Dai, Weidong2; Wei, Cong1; Kong, Hongwei2; Jia, Zhenhua1; Han, Jianke1; Zhang, Fengxia2; Wu, Zeming2; Gu, Yan2; Chen, Shili2; Gu, Qun2 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2011-08-25 |
| 卷号 | 56期号:1页码:86-92 |
| 关键词 | Metabonomics Urine Endothelial dysfunction LC-MS Tongxinluo Simvastatin |
| ISSN号 | 待补充 |
| 产权排序 | 1,1 |
| 通讯作者 | wuyiling ; 许国旺 |
| 中文摘要 | effect of the traditional chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry |
| 英文摘要 | a urinary metabonomic method based on ultra-fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (uflc/ms-it-tof) was employed to study the preventive efficacy and the metabolic changes caused by simavastatin and the traditional chinese medicine tongxinluo in endothelial dysfunction rats. principal component analysis (pca) was applied to study metabolic patterns of endothelial dysfunction rats and healthy control rats. 1-methyladenosine, indoxyl sulfate, hippuric acid, riboflavin, coproporphyrin, and p-cresol glucuronide were identified as potential biomarkers, indicating that pathways of adenine, tryptophan, phenylalanine, riboflavin, and porphyrin metabolism were disturbed in endothelial dysfunction rats. applications of simvastatin and tongxinluo to endothelial dysfunction rats improved endothelial function according to the results of histopathology and measurements of endothelin-1 and nitric oxide. metabonomic studies suggested that tongxinluo prevents endothelial dysfunction by regulating multiple metabolic pathways to their normal state, whereas simvastatin only altered selected metabolic pathways. this research demonstrated that metabonomics is a powerful and promising tool for disease investigation and the efficacy evaluation of complex traditional chinese medicines. (c) 2011 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | indoxyl sulfate ; oxidative stress ; uremic toxin ; p-cresol ; hplc-ms ; cells ; atherosclerosis ; metabolomics ; strategy ; systems |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000291913500012 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115670]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Integrat Tradit & Western Med Res Acad Hebei Prov, Shijiazhuang 050035, Hebei Province, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Weidong,Wei, Cong,Kong, Hongwei,et al. Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry[J]. journal of pharmaceutical and biomedical analysis,2011,56(1):86-92. |
| APA | Dai, Weidong.,Wei, Cong.,Kong, Hongwei.,Jia, Zhenhua.,Han, Jianke.,...&Xu, Guowang.(2011).Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry.journal of pharmaceutical and biomedical analysis,56(1),86-92. |
| MLA | Dai, Weidong,et al."Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry".journal of pharmaceutical and biomedical analysis 56.1(2011):86-92. |
入库方式： OAI收割
来源：大连化学物理研究所
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