Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter
文献类型：期刊论文
| 作者 | Yao, Zhenzhen2; Yin, Peiyuan1; Su, Dongwei3; Peng, Zhijun2; Zhou, Lina1; Ma, Long2; Guo, Wei2; Ma, Lie2; Xu, Guowang1; Shi, Junyi3 |
| 刊名 | molecular biosystems
 |
| 出版日期 | 2011 |
| 卷号 | 7期号:9页码:2608-2614 |
| ISSN号 | 待补充 |
| 产权排序 | 2,2 |
| 通讯作者 | 许国旺 ; shijunyi ; jiaobinhua |
| 中文摘要 | serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter |
| 英文摘要 | thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. however, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. thus, novel molecular markers that enable non-invasive diagnostics for malignant thyroid nodules are urgently needed. in the present study, a metabonomic investigation based on liquid chromatography-ltq orbitrap mass spectrometry was employed for serum metabolic profiling of 30 cases of papillary thyroid carcinomas (ptc), 80 cases of nodular goiters (benign thyroid nodules) and 30 cases of healthy controls. according to the results of multivariate statistical data analysis, the significantly changed metabolites among these three groups were defined. it was found that most of these metabolites decreased in the sera of both malignant and benign thyroid cases due to the increased metabolic rate, which is in accordance with clinical features. the major metabolic differences between benign and malignant nodules occurred in lipid metabolism. especially, the content of 3-hydroxybutyric acid, an intermediate product of fatty acid metabolism, was much higher in the ptc group than that in the nodule goiter and control groups, indicating its potential as a diagnostic marker for ptc and nodular goiters. these results show that the serum metabolic profiling method is a powerful tool for distinguishing thyroid carcinoma from nodular goiter and healthy controls. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemistry & molecular biology |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | fine-needle-aspiration ; global systems biology ; mass-spectrometry ; gene-expression ; cancer ; metabonomics ; diagnosis ; disease ; carnitine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000293648300010 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115684]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 3.Second Mil Med Univ, Dept Gen Surg 4, Changhai Hosp, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Zhenzhen,Yin, Peiyuan,Su, Dongwei,et al. Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter[J]. molecular biosystems,2011,7(9):2608-2614. |
| APA | Yao, Zhenzhen.,Yin, Peiyuan.,Su, Dongwei.,Peng, Zhijun.,Zhou, Lina.,...&Jiao, Binhua.(2011).Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter.molecular biosystems,7(9),2608-2614. |
| MLA | Yao, Zhenzhen,et al."Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter".molecular biosystems 7.9(2011):2608-2614. |
入库方式： OAI收割
来源：大连化学物理研究所
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