Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts
文献类型：期刊论文
| 作者 | He, Hongbing1,2; Ren, Xiaobin2; Wang, Xiyue1; Shi, Xianzhe1; Wang, Xiaolin1; Ding, Zhongjuan2; Gao, Peng1; Xu, Guowang1 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2012-02-05 |
| 卷号 | 59期号:待补充页码:130-137 |
| 关键词 | Rheumatoid arthritis Arachidonic acid Traditional Chinese Medicine Osteoblast Metabonomics |
| ISSN号 | 待补充 |
| 产权排序 | 1,1 |
| 通讯作者 | 高鹏 ; 许国旺 |
| 中文摘要 | therapeutic effect of yunnan baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts |
| 英文摘要 | in order to explore the potential therapeutic effect of yunnan baiyao (ynb) on rheumatoid arthritis (ra), rat models were constructed and orally administrated with ynb or methotrexate (mtx) in parallel. clinical physical, histological and biochemical parameters showed trivial therapeutic difference between ynb and mtx applications. urine and serum metabonomics results indicated that many endogenous metabolites differentially changed among the rats receiving diverse therapeutic interventions. among them, the fluctuation of arachidonic acid (aa) was thought to make sense. thus, its relevant metabolites were subjected to quantitation by using osteoblasts treated by ynb in vitro. it was found that ynb extract of 20 mu g/ml could greatly activate the synthesis of intracellular prostaglandin e(2) and thromboxane b(2) in osteoblasts. excretion of prostaglandin d(2) could be suppressed but not the thromboxane b(2). this study proved the efficacy of ynb on curing ra and its potential mechanism through modulating aa metabolism in osteoblasts to some extent. (c) 2011 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | collagen-induced arthritis ; mass-spectrometry ; signaling pathway ; protein-kinase ; methotrexate ; metabonomics ; rats ; sulfasalazine ; metabolomics ; mechanisms |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297716500018 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115685]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Kunming Med Univ, Affiliated Stomatol Hosp, Kunming 650031, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Hongbing,Ren, Xiaobin,Wang, Xiyue,et al. Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts[J]. journal of pharmaceutical and biomedical analysis,2012,59(待补充):130-137. |
| APA | He, Hongbing.,Ren, Xiaobin.,Wang, Xiyue.,Shi, Xianzhe.,Wang, Xiaolin.,...&Xu, Guowang.(2012).Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts.journal of pharmaceutical and biomedical analysis,59(待补充),130-137. |
| MLA | He, Hongbing,et al."Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts".journal of pharmaceutical and biomedical analysis 59.待补充(2012):130-137. |
入库方式： OAI收割
来源：大连化学物理研究所
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