Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives
文献类型：期刊论文
| 作者 | Wang, Lihua1; Wen, Ye1; Liu, Jie1; Zhou, Jun2; Li, Can2; Wei, Chunying1 |
| 刊名 | organic & biomolecular chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:8页码:2648-2653 |
| ISSN号 | 待补充 |
| 产权排序 | 2,4 |
| 通讯作者 | 魏春英 |
| 中文摘要 | promoting the formation and stabilization of human telomeric g-quadruplex dna, inhibition of telomerase and cytotoxicity by phenanthroline derivatives |
| 英文摘要 | four new di-substituted phenanthroline-based compounds a-d have been designed and prepared, and they have been shown to induce the formation of anti-parallel structure of human telomeric g-quadruplex dna by cd spectra. fret assay indicates that the melting temperature increases (delta t-m values) of g-quadruplex in buffer (ph 7.4) containing 100 mm nacl are 31.6, 34.6, 17.8 and 32.6 degrees c for the compounds (1.0 mu m) a, b, c and d, respectively. competitive fret assay shows that the four compounds exhibit a high g-quadruplex dna selectivity over duplex dna. three of the compounds are the potent telomerase inhibitors and hela cell proliferation inhibitors. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | intramolecular g-quadruplex ; ligands ; complexes ; recognition ; binding ; protocol ; hybrid ; forms |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000288904500013 |
| 公开日期 | 2012-07-09 |
| 源URL | [http://159.226.238.44/handle/321008/115744]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, BState Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lihua,Wen, Ye,Liu, Jie,et al. Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives[J]. organic & biomolecular chemistry,2011,9(8):2648-2653. |
| APA | Wang, Lihua,Wen, Ye,Liu, Jie,Zhou, Jun,Li, Can,&Wei, Chunying.(2011).Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives.organic & biomolecular chemistry,9(8),2648-2653. |
| MLA | Wang, Lihua,et al."Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives".organic & biomolecular chemistry 9.8(2011):2648-2653. |
入库方式： OAI收割
来源：大连化学物理研究所
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