Bile acids as Novel Indicator of Hepatocellular Carcinoma: Small-Molecule Markers Screening from Bile Fluid to Serum
文献类型：会议论文
| 作者 | Wang WZ(王文昭) ; YexiongTan ; YiHong ; Yin PY(尹沛源) ; LiangTang ; Gao P(高鹏) ; MinWang ; Huang Q(黄强) ; Chen J(陈静) ; Li X(李响) ; LiweiDong ; Zhao XJ(赵欣捷) ; ZhenzhenYao ; Lu X(路鑫) ; Xu GW(许国旺) ; HongyangWang |
| 出版日期 | 2011 |
| 会议名称 | 37th international symposium on high performance liquid phase separations and related techniques |
| 会议日期 | 2011-10-8 |
| 会议地点 | 大连 |
| 页码 | 487-0 |
| 通讯作者 | 许国旺 |
| 中文摘要 | the identification of a sensitive and specific serum marker will facilitate the early diagnosis of hepatocellular carcinoma (hcc) and increase patient survival rates. in this study, bile fluid from 82 patients suffering from hepatic carcinoma (n=40), gall-stone (n=20), cystic polypi (n=15) and hepatic benign lesions (n=7) were analyzed through a high-efficient ultra performance liquid chromatography (uplc) mass spectrometry metabolic profiling strategy. the acquired data were subjected to orthogonal signal correction-partial least squares discriminate analysis (osc-plsda) to extract the significant bile fluid components that played a key role in defining the disease state. subsequently, univariate analysis was utilized to narrow the scope of potential metabolic markers that were hcc specific. finally, a bile acid that had elevated concentrations in the bile fluid as well as in the sera of hcc patients was screened out. by using this bile acid as a marker, the hcc screening sensitivity increased from 62% (based on alpha-fetoprotein, afp) to 93%. conclusion: these findings demonstrated that bile acid would be useful serum indicator for hcc diagnosis. |
| 合作状况 | 墙报 |
| 会议主办者 | 中国化学会色谱专业委员会 |
| 会议录 | proceeding of hplc 2011
 |
| 会议录出版者 | 待补充 |
| 学科主题 | 分析化学 |
| 会议录出版地 | 待补充 |
| 源URL | [http://159.226.238.44/handle/321008/116070]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang WZ,YexiongTan,YiHong,et al. Bile acids as Novel Indicator of Hepatocellular Carcinoma: Small-Molecule Markers Screening from Bile Fluid to Serum[C]. 见:37th international symposium on high performance liquid phase separations and related techniques. 大连. 2011-10-8. |
入库方式： OAI收割
来源：大连化学物理研究所
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