Cytotoxic Triterpenoids from Azadirachta indica
文献类型：期刊论文
| 作者 | Chen, JinXiong2; Chen, JianChao; Sun, Yun2; Yan, YuXin2; Kong, LingMei2; Li, Yan ; Qiu, MingHua1
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 77期号:16页码:1844-1847 |
| 关键词 | Meliaceae Azadirachta indica tirucallane triterpenoid tetranortriterpenoid cytotoxicity |
| ISSN号 | 0032-0943 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 LanHei Rd, Kunming 650204, Yunnan, Peoples R China |
| 英文摘要 | Two new tirucallane triterpenoids, 24,25-epoxy-3 beta-hydroxy-20-oxo- 7-tirucallene (1) and 22,23; 24,25-diepoxy-3 beta-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4 alpha-hydroperoxy- 6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC(50) values of 0.8 +/- 0.1, 2.2 +/- 0.2, 1.9 +/- 1.3, 4.5 +/- 1.1, and 2.3 +/- 0.1 mu M, respectively. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | NEEM ; TETRANORTRITERPENOIDS ; MELIACEAE |
| 收录类别 | SCI |
| 资助信息 | Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]; CAS[KSCX2-YW-G-038, KSCX2-EW-R-15, KSCX2-YW-R-194, KZCX2-XB2-15-03] |
| 语种 | 英语 |
| WOS记录号 | WOS:000296725500015 |
| 公开日期 | 2012-07-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/13569]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, JinXiong,Chen, JianChao,Sun, Yun,et al. Cytotoxic Triterpenoids from Azadirachta indica[J]. PLANTA MEDICA,2011,77(16):1844-1847. |
| APA | Chen, JinXiong.,Chen, JianChao.,Sun, Yun.,Yan, YuXin.,Kong, LingMei.,...&Qiu, MingHua.(2011).Cytotoxic Triterpenoids from Azadirachta indica.PLANTA MEDICA,77(16),1844-1847. |
| MLA | Chen, JinXiong,et al."Cytotoxic Triterpenoids from Azadirachta indica".PLANTA MEDICA 77.16(2011):1844-1847. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。