Cytotoxic Steroids from Sarcococca saligna
文献类型：期刊论文
| 作者 | Yan, Yu-Xin1,2; Sun, Yun1,2; Chen, Jian-Chao1; Wang, Yuan-Yuan1; Li, Yan1 ; Qiu, Ming-Hua1
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2011-10-01 |
| 卷号 | 77期号:15页码:1725-1729 |
| 关键词 | Buxaceae Sarcococca saligna sarsaligates A/B sarsaligenines A/B cytotoxicity |
| ISSN号 | 0032-0943 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, 134 Lan Hei Rd, Kunming 650204, Peoples R China |
| 英文摘要 | Two new C(21)-steroidal esters, sarsaligates A (1) and B (2), and two new steroidal alkaloids, sarsaligenines A (3) and B (4), together with four known compounds (sarcovagine, sarcorucinine, dimethylamino-3 beta-pregnane-20-one, and beta-sitosterol 5-8, respectively), were isolated from the leaves and stems of Sarcococca saligna. The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis. Of the compounds tested, 5 and 6 were the most cytotoxic against the cell lines K562, SK-BR-3, and PANC-1, with IC50 values in the range of 2.25-5.00 mu M, while 3 and 4 selectively inhibited HL-60 cells with IC(50) values of 2.87 and 3.61 mu M, respectively. Compounds 3-6 therefore deserve further evaluation of their cytotoxic potentials. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | ALKALOIDS ; HOOKERIANA ; VAGANS ; ROOTS |
| 收录类别 | SCI |
| 资助信息 | CAS[KSCX2-YW-G-038, 027, KSCX2-YW-R-194, 29, KZCX2-XB2-15-03]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14] |
| 语种 | 英语 |
| WOS记录号 | WOS:000296188000010 |
| 公开日期 | 2012-07-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/13573]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,et al. Cytotoxic Steroids from Sarcococca saligna[J]. PLANTA MEDICA,2011,77(15):1725-1729. |
| APA | Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,Wang, Yuan-Yuan,Li, Yan,&Qiu, Ming-Hua.(2011).Cytotoxic Steroids from Sarcococca saligna.PLANTA MEDICA,77(15),1725-1729. |
| MLA | Yan, Yu-Xin,et al."Cytotoxic Steroids from Sarcococca saligna".PLANTA MEDICA 77.15(2011):1725-1729. |
入库方式： OAI收割
来源：昆明植物研究所
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