Henrylactones A-E and Anti-HBV Constituents from Illicium henryi
文献类型：期刊论文
| 作者 | Liu, Ji-Feng1,2; Jiang, Zhi-Yong1; Zhang, Quan1,2; Shi, Yao; Ma, Yun-Bao1; Xie, Ming-Jin3; Zhang, Xue-Mei1 ; Chen, Ji-Jun1,2
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2010 |
| 卷号 | 76期号:2页码:152-158 |
| 关键词 | Illiciaceae Illicium henryi sesquiterpene lactone henrylactones A-E anti-HBV activity |
| ISSN号 | 0032-0943 |
| 英文摘要 | Five new sesquiterpene lactones, henrylactones A-E (1-5), together with ten known compounds: cycloparvifloralone (6), tashironin (7), tashironin A (8), neoanisatin (9), anisatin (10), anislactone B (11), 7-O-acetylanislactone B (12), merrillianolide (13), cyclomerrillianolide (14) and pseudomajucin (15), were isolated from the stems and roots of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses. Among them, henrylactone A (1) is a novel sesquiterpene with a dilactone moiety and its structure was confirmed by X-ray diffraction. Sesquiterpene lactones 1-15 were tested for their anti-hepatitis B virus (HBV) activities. The most active compound, tashironin (7), exhibited an IC(50) value of 0.48 mM (SI = 6.3) inhibiting on HBV surface antigen (HBsAg) secretion and an IC(50) value of 0.15 mM(SI = 20.1) inhibiting on HBV e antigen (HBeAg) secretion using HBV transfected Hep G2.2.15 cell line. |
| 学科主题 | Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | PREZIZAANE-TYPE SESQUITERPENES ; NEUROTROPHIC ACTIVITY ; ANISLACTONE-B ; MERRILLIANUM ; PERICARPS ; LACTONES ; ANISATUM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274261100009 |
| 公开日期 | 2012-07-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/13587]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Yunnan Univ, Dept Chem, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ji-Feng,Jiang, Zhi-Yong,Zhang, Quan,et al. Henrylactones A-E and Anti-HBV Constituents from Illicium henryi[J]. PLANTA MEDICA,2010,76(2):152-158. |
| APA | Liu, Ji-Feng.,Jiang, Zhi-Yong.,Zhang, Quan.,Shi, Yao.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2010).Henrylactones A-E and Anti-HBV Constituents from Illicium henryi.PLANTA MEDICA,76(2),152-158. |
| MLA | Liu, Ji-Feng,et al."Henrylactones A-E and Anti-HBV Constituents from Illicium henryi".PLANTA MEDICA 76.2(2010):152-158. |
入库方式： OAI收割
来源：昆明植物研究所
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