Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation
文献类型：期刊论文
| 作者 | Qing, C; Liu, MH; Yangl, WM; Zhang, YL; Wang, L ; Liu, JK
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2004-09-01 |
| 卷号 | 70期号:9页码:792-796 |
| ISSN号 | 0032-0943 |
| 关键词 | albaconol Albatrellaceae Albatrellus confluens antitumor activity topoisomerase |
| 英文摘要 | The effect of albaconol on the growth of human tumor cell, DNA topoisomerase (topo)-mediated DNA cleavage and direct DNA breakage was investigated. Albaconol inhibited significantly the growth of the human tumor cell lines K562, A549, BGC-823 and Bcap-37, the IC50 values were 7.99+/-0.4, 3.17+/-0.89, 4.18+/-0.14 and 7.45+/-2.5 muM, respectively. Albaconol stabilized and increased the topo II-mediated DNA cleavable complex and inhibited the religation activity of topo II in a dose-dependent manner, but it failed to affect the activity of topo I. Albaconol directly broke pBR322 DNA at high concentrations, but there was no effect on the macromolecule of K562 cells. These results strongly suggest that albaconol targeted specifically to DNA topo II and that this is one of the mechanisms of its antitumor action; the direct action of albaconol on DNA may partly contribute to its antitumor activity at high concentrations. |
| 学科主题 | Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | CELL-LINES ; PROLIFERATION ; DOXORUBICIN ; ASSAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224440700003 |
| 公开日期 | 2012-07-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/13613]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qing, C,Liu, MH,Yangl, WM,et al. Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation[J]. PLANTA MEDICA,2004,70(9):792-796. |
| APA | Qing, C,Liu, MH,Yangl, WM,Zhang, YL,Wang, L,&Liu, JK.(2004).Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation.PLANTA MEDICA,70(9),792-796. |
| MLA | Qing, C,et al."Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation".PLANTA MEDICA 70.9(2004):792-796. |
入库方式： OAI收割
来源：昆明植物研究所
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