Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions
文献类型：期刊论文
| 作者 | Shen, ZQ; Dong, ZJ ; Cheng, P; Li, L; Chen, ZH; Liu, J
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2003-07-01 |
| 卷号 | 69期号:7页码:605-609 |
| 关键词 | plumbagin platelet aggregation platelet-neutrophil interactions |
| ISSN号 | 0032-0943 |
| 英文摘要 | The effects of plumbagin were investigated on platelet aggregation in vitro and ex vivo, on the binding of thrombin-stimulated platelets to neutrophils, and platelet aggregation induced by intact neutrophils and N-formyt-methionyl-leucyl-phenylalanine (fMLP) or platelet activating factor (PAF) activated neutrophils, by use of the methods of Hamburger, McEver and Born, respectively. The results showed that plumbagin in vitro significantly inhibited adenosine diphosphate (ADP)-, arachidonic acid (AA)-, or platelet activating factor (PAF)-induced platelet aggregation, in a concentration-dependent manner. The medium inhibitory concentrations (IC50) were 39.4, 82.7 and 38.1 muM respectively. Intragastric plumbagin at 10 mg/kg markedly suppressed platelet aggregation induced by ADP, AA, or PAF. Plumbagin decreased the binding between thrombin-stimulated platelets and neutrophils with an IC50 of 62.9 muM. Plumbagin significantly inhibited washed platelet aggregation stimulated by fMLP- or PAF-activated neutrophils. The IC50 values were 54.3 and 47.6 muM, respectively. On the other hand, plumbagin and aspirin increased the inhibition of intact neutrophils on AA-induced platelet aggregation. It is suggested that plumbagin inhibited platelet aggregation in vitro and ex vivo, suppressed the binding of activated platelets to neutrophils, inhibited platelet aggregation induced by activated neutrophils, and increased inhibition of intact neutrophils on platelet reactivity. |
| 学科主题 | Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | BLOOD-PLATELETS ; ADHESION ; GMP-140 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184890000003 |
| 公开日期 | 2012-07-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/13621]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, ZQ,Dong, ZJ,Cheng, P,et al. Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions[J]. PLANTA MEDICA,2003,69(7):605-609. |
| APA | Shen, ZQ,Dong, ZJ,Cheng, P,Li, L,Chen, ZH,&Liu, J.(2003).Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions.PLANTA MEDICA,69(7),605-609. |
| MLA | Shen, ZQ,et al."Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions".PLANTA MEDICA 69.7(2003):605-609. |
入库方式： OAI收割
来源：昆明植物研究所
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