Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response
文献类型：期刊论文
| 作者 | Wu, Gui-Sheng2 ; Luo, Huai-Rong2; Dong, Chuanhui3,4; Mastronardi, Claudio1; Licinio, Julio1; Wong, Ma-Li1
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| 刊名 | PSYCHIATRIC GENETICS
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| 出版日期 | 2011-02-01 |
| 卷号 | 21期号:1页码:14-18 |
| 关键词 | antidepressant association haplotype major depression melanocortin 1 receptor single nucleotide polymorphisms |
| ISSN号 | 0955-8829 |
| 通讯作者 | Wong, ML (reprint author), Australian Natl Univ, John Curtin Sch Med Res, Bldg 131,Garran Rd, Canberra, ACT 2601, Australia |
| 英文摘要 | Objective Melanocortin 1 receptor (MC1R) is involved in various functions, such as pigmentation, antipyretic and anti-inflammatory actions, development of melanoma, susceptibility to ultraviolet-induced sun damage, modification of oculocutaneous albinism, development of freckles, and mediation of female-specific mechanisms of analgesia. MC1R's natural agonists include a-melanocyte-stimulating hormone and corticotrophin (ACTH1-39), which are important components of hypothalamic pituitary adrenal axis and increase in response to stress. Given the multiple relevant roles of MC1R, we studied whether the MC1R gene would be associated with susceptibility to major depressive disorder or with response to antidepressant treatment. |
| 学科主题 | Genetics & Heredity; Neurosciences & Neurology |
| 类目[WOS] | Genetics & Heredity ; Neurosciences |
| 研究领域[WOS] | Genetics & Heredity ; Neurosciences & Neurology |
| 关键词[WOS] | MELANOCYTE-STIMULATING HORMONE ; MELANOCORTIN-1 RECEPTOR ; MAJOR DEPRESSION ; ALPHA-MSH ; RED HAIR ; DESIPRAMINE ; EXPRESSION ; HUMANS ; SUSCEPTIBILITY ; MODULATION |
| 收录类别 | SCI |
| 资助信息 | University of Miami, Department of Psychiatry and Behavioral Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000285544800003 |
| 公开日期 | 2012-07-25 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/14467]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Ctr Drug Screening & Res, Beijing 100864, Yunnan, Peoples R China 3.Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA 4.Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA |
| 推荐引用方式 GB/T 7714 | Wu, Gui-Sheng,Luo, Huai-Rong,Dong, Chuanhui,et al. Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response[J]. PSYCHIATRIC GENETICS,2011,21(1):14-18. |
| APA | Wu, Gui-Sheng,Luo, Huai-Rong,Dong, Chuanhui,Mastronardi, Claudio,Licinio, Julio,&Wong, Ma-Li.(2011).Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response.PSYCHIATRIC GENETICS,21(1),14-18. |
| MLA | Wu, Gui-Sheng,et al."Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response".PSYCHIATRIC GENETICS 21.1(2011):14-18. |
入库方式： OAI收割
来源：昆明植物研究所
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