Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A
文献类型：期刊论文
| 作者 | Wei, TT; Sun, HD ; Zhao, XY; Hou, JW; Hou, AJ; Zhao, QS; Xin, WJ
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2002-03-08 |
| 卷号 | 70期号:16页码:1889-1899 |
| 关键词 | Pistafolia A gallotannin free radical cerebellar granule cell oxidative stress apoptosis |
| 英文摘要 | Pistafolia A is a novel gallotannin isolated from the leaf extract of Pastacia weinmannifolia. In the present investigation, the ability of Pistafolia A to scavenge reactive oxygen species including hydroxyl radicals and superoxide anion was treasured by ESR spin trapping technique. The inhibition effect on iron-induced lipid peroxidaiton in liposomes was studied. The protective effects of Pistafolia A against oxidative neuronal cell damage and apoptosis induced by peroxynitrite were also assessed. The results showed that Pistafolia A could scavenge both hydroxyl radicals and superoxide anion dose-dependently and inhibit lipid peroxidation effectively. In cerebellar granule cells pretreated with Pistafolia A, peroxynitrite-induced oxidative neuronal damage and apoptosis were prevented markedly. The antioxidant capacity of Pistafolia A was much more potent then that of the water-soluble analog of vitamin E, Trolox. The results suggested that Pistafolia A might be used as an effective natural antioxidant for the prevention and cure of neuronal diseases associated with the production of peroxynitrite and related reactive oxygen species. (C) 2002 Elsevier Science Inc. All rights reserved. |
| 学科主题 | Medicine, Research & Experimental; Pharmacology & Pharmacy |
| 类目[WOS] | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 关键词[WOS] | ANTIOXIDANT ; ACID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000174822100005 |
| 公开日期 | 2012-07-25 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/14607]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Dept Mol & Cellular Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, TT,Sun, HD,Zhao, XY,et al. Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A[J]. LIFE SCIENCES,2002,70(16):1889-1899. |
| APA | Wei, TT.,Sun, HD.,Zhao, XY.,Hou, JW.,Hou, AJ.,...&Xin, WJ.(2002).Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A.LIFE SCIENCES,70(16),1889-1899. |
| MLA | Wei, TT,et al."Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A".LIFE SCIENCES 70.16(2002):1889-1899. |
入库方式： OAI收割
来源：昆明植物研究所
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