CYTOTOXIC ACTIVITY OF TREWIASINE IN 4 HUMAN CANCER CELL-LINES AND 5 MURINE TUMORS
文献类型：期刊论文
| 作者 | WANG, C
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992 |
| 卷号 | 13期号:3页码:252-255 |
| 关键词 | TREWIASINE MAYTANSINE CULTURED TUMOR CELLS EXPERIMENTAL NEOPLASMS PHYTOGENIC ANTINEOPLASTIC AGENTS |
| ISSN号 | 0253-9756 |
| 英文摘要 | Trewiasine (TWS) is a mytansinoid compound. It possessed a significant cytotoxic activity against various human cancer cell lines in vitro. U937 cells, which were more sensitive to the TWS, required TWS 1-mu-g . ml-1 to inhibit cell growth over 90% (P < 0.01). TWS also showed activities against murine tumors in vivo, such as the ascitic tumors S180, hepatoma, U14, and solid tumor Lewis lung carcinoma. Depression of leukocytes was not seen when mice were given ip TWS 10 or 50-mu-g . kg-1 . d-1 x 7 d. TWS 0.1-1-mu-g . ml-1 caused no sister chromatid exchange induction in Chinese hamster cell line V79. |
| 学科主题 | Chemistry, Multidisciplinary; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-25 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/14377]  |
| 专题 | 昆明植物研究所_离退休 |
| 推荐引用方式 GB/T 7714 | WANG, C. CYTOTOXIC ACTIVITY OF TREWIASINE IN 4 HUMAN CANCER CELL-LINES AND 5 MURINE TUMORS[J]. ACTA PHARMACOLOGICA SINICA,1992,13(3):252-255. |
| APA | WANG, C.(1992).CYTOTOXIC ACTIVITY OF TREWIASINE IN 4 HUMAN CANCER CELL-LINES AND 5 MURINE TUMORS.ACTA PHARMACOLOGICA SINICA,13(3),252-255. |
| MLA | WANG, C."CYTOTOXIC ACTIVITY OF TREWIASINE IN 4 HUMAN CANCER CELL-LINES AND 5 MURINE TUMORS".ACTA PHARMACOLOGICA SINICA 13.3(1992):252-255. |
入库方式： OAI收割
来源：昆明植物研究所
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