Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
文献类型：期刊论文
| 作者 | Gao, Shu-Shan1,2; Li, Xiao-Ming1; Du, Feng-Yu1; Li, Chun-Shun1; Proksch, Peter3; Wang, Bin-Gui1
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2011 |
| 卷号 | 9期号:1页码:59-70 |
| 关键词 | marine endophyte Penicillium chrysogenum secondary metabolites |
| ISSN号 | 1660-3397 |
| 中文摘要 | Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia, displayed inhibitory activity against the growth of pathogen Alternaria brassicae in dual culture test. Chemical investigation of this fungal strain resulted in the isolation of four new (1-3 and 5) and one known (4) secondary metabolites. Their structures were identified as two polyketide derivatives penicitides A and B (1 and 2), two glycerol derivatives 2-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (3) and 1-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (4), and one monoterpene derivative penicimonoterpene (5). Penicitides A and B (1 and 2) feature a unique 10-hydroxy-or 7,10-dihydroxy-5,7-dimethylundecyl moiety substituting at C-5 of the alpha-tetrahydropyrone ring, which is not reported previously among natural products. Compound 5 displayed potent activity against the pathogen A. brassicae, while compound 1 exhibited moderate cytotoxic activity against the human hepatocellular liver carcinoma cell line. |
| 英文摘要 | Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia, displayed inhibitory activity against the growth of pathogen Alternaria brassicae in dual culture test. Chemical investigation of this fungal strain resulted in the isolation of four new (1-3 and 5) and one known (4) secondary metabolites. Their structures were identified as two polyketide derivatives penicitides A and B (1 and 2), two glycerol derivatives 2-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (3) and 1-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (4), and one monoterpene derivative penicimonoterpene (5). Penicitides A and B (1 and 2) feature a unique 10-hydroxy-or 7,10-dihydroxy-5,7-dimethylundecyl moiety substituting at C-5 of the alpha-tetrahydropyrone ring, which is not reported previously among natural products. Compound 5 displayed potent activity against the pathogen A. brassicae, while compound 1 exhibited moderate cytotoxic activity against the human hepatocellular liver carcinoma cell line. |
| 学科主题 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 原文出处 | 10.3390/md9010059 |
| 语种 | 英语 |
| WOS记录号 | WOS:000288892000004 |
| 公开日期 | 2012-07-03 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/11938]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany |
| 推荐引用方式 GB/T 7714 | Gao, Shu-Shan,Li, Xiao-Ming,Du, Feng-Yu,et al. Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S[J]. MARINE DRUGS,2011,9(1):59-70. |
| APA | Gao, Shu-Shan,Li, Xiao-Ming,Du, Feng-Yu,Li, Chun-Shun,Proksch, Peter,&Wang, Bin-Gui.(2011).Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S.MARINE DRUGS,9(1),59-70. |
| MLA | Gao, Shu-Shan,et al."Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S".MARINE DRUGS 9.1(2011):59-70. |
入库方式： OAI收割
来源：海洋研究所
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