A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells
文献类型：期刊论文
| 作者 | Liu, Ling1; Wu, Junhua1; Zhang, Jinlu1; Li, Zhenjing1; Wang, Changlu1; Chen, Mianhua1; Wang, Yurong1; Sun, Yuanxia2; Wang, Likui3; Luo, Cheng1 |
| 刊名 | JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 10期号:2页码:111-114 |
| 关键词 | Exopolysaccharide (EPS) ursolic acid (VA) anti-proliferation antioxidants MTT assay synergy |
| 英文摘要 | Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent, which produces harmful free radicals. However, natural antioxidants possess antioxidative properties and exogenous antioxidants are normally capable of inhibiting the oxidation in an organism. The synergy of different antioxidants would reverse the oxidation to a greater extent compared with a single antioxidant. We analyzed ursolic acid (UA) together with foodborne phosphate-containing viili exopolysaccharides (EPS) for antioxidant activities, and anti-proliferation properties of cancer cells. The strong antioxidant capacity of UA was observed at concentrations of 100 mu g/ml in ferric reducing antioxidant power test, where mild synergy with viili EPS was visible. Interestingly viili EPS had as strong antioxidative power as UA for the free radical scavenging activity in Fenton assay. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay with hepatoma HepG2 cells, the mild, but significant anti-proliferation by UA and EPS was seen at concentration of 200 mu g/ml, a synergic inhibition were particularly seen at 12.5 mu g/ml with a ratio of 3:2 EPS and UA. The senescence of HepG2 cancer cells after the combined treatment of UA and viili EPS at 12.5 mu g/ml were observed. These data indicated that UA is compatible with North European diets together with potential antioxidative and anti-proliferation complement modulating activities. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Food Science & Technology |
| 研究领域[WOS] | Food Science & Technology |
| 关键词[WOS] | MESENTEROIDES SSP CREMORIS ; VIILI ; CYCLOOXYGENASE-2 ; POLYSACCHARIDES ; SUPPRESSION ; PROBIOTICS ; SBT-0495 ; SYSTEM ; MILK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304335900017 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://localhost/handle/0/258]  |
| 专题 | 天津工业生物技术研究所_功能糖与天然活性物质研究组 孙媛霞 _期刊论文 |
| 作者单位 | 1.Tianjin Univ Sci & Technol, Key Lab Food Nutr & Safely, Minist Educ, Sch Food Engn & Biotechnol, Tianjin 300457, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300457, Peoples R China 3.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ling,Wu, Junhua,Zhang, Jinlu,et al. A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells[J]. JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT,2012,10(2):111-114. |
| APA | Liu, Ling.,Wu, Junhua.,Zhang, Jinlu.,Li, Zhenjing.,Wang, Changlu.,...&Luo, Cheng.(2012).A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells.JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT,10(2),111-114. |
| MLA | Liu, Ling,et al."A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells".JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT 10.2(2012):111-114. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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