Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis
文献类型：期刊论文
| 作者 | Haribabu Ankati ; Dunming Zhu ; Yan Yang ; Edward R. Biehl ; Ling Hua |
| 刊名 | Journal of Organic Chemistry
 |
| 出版日期 | 2009-02-20 |
| 卷号 | 74期号:4页码:1658-1662 |
| 英文摘要 | Use of isolated carbonyl reductases in the reduction of aromatic beta-ketonitriles have completely eliminated the competing alpha-ethylation, which is often observed with whole cell biocatalysts. By choosing suitable recombinant carbonyl reductase, the reduction of beta-ketonitriles afforded (R)- or (S)-beta-hydroxy nitrites with excellent optical purity and yield. Subsequently, nitrilase-catalyzed hydrolysis of the obtained optically pure beta-hydroxy nitrites led to the corresponding beta-hydroxy carboxylic acids in high yields. More importantly, the sequential enzymatic reduction and hydrolysis could be carried out in "two-step-one-pot" fashion without the isolation of intermediates alpha-hydroxy nitrites, lowering the cost and minimizing the environmental impact. This allows ready access to both antipodes of chiral beta-hydroxy nitrites and beta-hydroxy carboxylic acids of pharmaceutical importance with excellent optical purity. |
| 公开日期 | 2011-08-16 |
| 源URL | [http://localhost/handle/0/80]  |
| 专题 | 天津工业生物技术研究所_生物催化与绿色化工 朱敦明_期刊论文 |
| 推荐引用方式 GB/T 7714 | Haribabu Ankati,Dunming Zhu,Yan Yang,et al. Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis[J]. Journal of Organic Chemistry,2009,74(4):1658-1662. |
| APA | Haribabu Ankati,Dunming Zhu,Yan Yang,Edward R. Biehl,&Ling Hua.(2009).Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis.Journal of Organic Chemistry,74(4),1658-1662. |
| MLA | Haribabu Ankati,et al."Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis".Journal of Organic Chemistry 74.4(2009):1658-1662. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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