Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia
文献类型：期刊论文
| 作者 | Nian, Yin1,2 ; Wang, Hai-Yan1,2; Su, Jia1,2; Zhou, Lin1; Feng, Gang1; Li, Yan1; Qiu, Ming-Hua1
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2012-08-12 |
| 卷号 | 68期号:32页码:6521-6527 |
| 关键词 | Cimicifuga heracleifolia Cycloartane triterpenes Cytotoxicity Structure-activity relationships |
| ISSN号 | 0040-4020 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 英文摘要 | Phytochemical investigation on the roots of Cimicifuga heracleifolia afforded nine new 9,19-cycloartane triterpenes (1-9), along with seven known constituents (10-16). The new structures were elucidated by spectroscopic and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that eight cimigenol-type compounds (1-3,5, 10-12,14) showed different levels of cytotoxic activities, with IC50 values ranging from 0.83 to 23.94 mu M. In addition, their structural and bioactive features enriched the structure-activity relationships we proposed before. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SEQUENCE VARIATION ; SIMPLEX WORMSK ; CELL-CYCLE ; CIMISIDE E ; FOETIDA L ; CONSTITUENTS ; GLYCOSIDES ; RANUNCULACEAE ; PHYLOGENY ; APOPTOSIS |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China[U1132604]; Knowledge Innovation Program of the CAS[KZCX2-XB2-15-03, KSCX2-EW-R-15]; top talents program of Yunnan province[2009C1120]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ14] |
| 语种 | 英语 |
| WOS记录号 | WOS:000306267800017 |
| 公开日期 | 2012-09-03 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/15081]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Wang, Hai-Yan,Su, Jia,et al. Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia[J]. TETRAHEDRON,2012,68(32):6521-6527. |
| APA | Nian, Yin.,Wang, Hai-Yan.,Su, Jia.,Zhou, Lin.,Feng, Gang.,...&Qiu, Ming-Hua.(2012).Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia.TETRAHEDRON,68(32),6521-6527. |
| MLA | Nian, Yin,et al."Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia".TETRAHEDRON 68.32(2012):6521-6527. |
入库方式： OAI收割
来源：昆明植物研究所
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