Expression of survivin and correlation with PCNA in osteosarcoma
文献类型：期刊论文
| 作者 | Wang AQ(王爱勤)
|
| 刊名 | Journal of Surgical Oncology
 |
| 出版日期 | 2006 |
| 卷号 | 93页码:578-584 |
| 关键词 | osteosarcoma surviving PCNA immunohistochemistry |
| ISSN号 | 0022-4790 |
| 通讯作者 | 王爱勤 aqwang@licp.cas.cn |
| 中文摘要 | Background and Objectives: Survivin is a new anti-apoptosis gene with reported expression during fetal development and in cancer tissues. Proliferating cell nuclear antigen (PCNA) is essential for the replication of deoxyribonucleic acid (DNA). In this experiment, we examined the expression of survivin and PCNA in human osteosarcoma tissues and investigating whether survivin and PCNA expressions were correlated with histological grades, histological types, and patients' clinical characteristics. Methods: Sixty-eight osteosarcoma samples were divided into two groups based on the degree of tumor cell differentiation. Immunohistochemical staining was performed to analyze the expression of survinin and PCNA. Four histological types and patients' clinical characteristics were also recorded. Results: There were abundant levels of survivin and PCNA immunoreactivity in the nucleus and/or cytoplasm of the osteosarcoma cells. All cells essentially revealed the cytoplasmic localization and the nuclear signals of survivin in same cases, while PCNA from the majority of cases predominantly showed nuclear expression. Scoring on the percentage of positive cells indicated that survivin expression was significantly associated with the PCNA-labeling index (LI), which was correlated with the histological grades of osteosarcoma (χ2?=?17.86 and χ2?=?23.75, respectively). Conclusions: The expression of survivin can be used as a useful indicator in grading the malignancy of osteosarcoma. |
| 学科主题 | 药学 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237894500012 |
| 公开日期 | 2012-09-02 |
| 源URL | [http://210.77.64.217/handle/362003/236]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 推荐引用方式 GB/T 7714 | Wang AQ. Expression of survivin and correlation with PCNA in osteosarcoma[J]. Journal of Surgical Oncology,2006,93:578-584. |
| APA | 王爱勤.(2006).Expression of survivin and correlation with PCNA in osteosarcoma.Journal of Surgical Oncology,93,578-584. |
| MLA | 王爱勤."Expression of survivin and correlation with PCNA in osteosarcoma".Journal of Surgical Oncology 93(2006):578-584. |
入库方式： OAI收割
来源：兰州化学物理研究所
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