Association between intelligence and COMT genotypes in Chinese healthy children
文献类型：会议论文
| 作者 | Shi JN(施建农)
|
| 出版日期 | 2010 |
| 会议名称 | 4th International Conference on Bioinformatics and Biomedical Engineering |
| 会议日期 | 2010 |
| 会议地点 | Chengdu, China |
| 关键词 | Intelligence Catechol-O-methyl transferase (COMT) functional polymorphism |
| 中文摘要 | Catechol-O-methyl transferase (COMT) influences dopamine concentration in the pre-frontal cortex (PFC). The G/A transition in the exon 4 of the COMT gene, which results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met), can bring on different enzymatic activities. Much research has found that the Met/Met genotype associated with low enzymatic activity and may enhance cognitive function. We applied one-way ANOVA to detect the effect of the COMT genotypes to intelligence in 108 Chinese children with polymerase chain reaction (PCR) methods. We found COMT Val158Met polymorphism had a significant main effect on intelligence (F (2, 102) = 3.47, p=0.035) and it could predict 4.7% of intelligence. Our results also suggest that Met/Met genotype has a positive effect on intelligence. However, we found no significant interaction between gender and COMT genotype to intelligence. |
| 语种 | 英语 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/8827]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 推荐引用方式 GB/T 7714 | Shi JN. Association between intelligence and COMT genotypes in Chinese healthy children[C]. 见:4th International Conference on Bioinformatics and Biomedical Engineering. Chengdu, China. 2010. |
入库方式： OAI收割
来源：心理研究所
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