Association between creativity and COMT genotype
文献类型：会议论文
| 作者 | Shi JN(施建农)
|
| 出版日期 | 2010 |
| 会议名称 | 2010 4th International Conference on Bioinformatics and Biomedical Engineering |
| 会议日期 | 2010 |
| 会议地点 | Chengdu, China |
| 关键词 | creative ability creative potential Catechol-O-methyl transferase (COMT) functional polymorphism |
| 中文摘要 | Catechol-O-methyl transferase (COMT) influences dopamine concentration in the pre-frontal cortex (PFC). The G/A transition in the exon 4 of the COMT gene, which results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met), can bring on different enzymatic activities. Much research has found that the Met/Met genotype associated with low enzymatic activity and may enhance cognitive function. Our research aimed to test the association between COMT genotype and creativity. We applied one-way ANOVA to detect the effect of the COMT genotypes to creative ability and creative potentials in 108 Chinese children with polymerase chain reaction (PCR) methods. COMT genotypes were not related to creative ability and creative potential except imagination. Val/Val carriers are more likely to imagine than Met/Met carriers (F (2, 105) =4.082, p=.02). We also found that COMT Val158Met polymorphism had a significant main effect on intelligence (F (2, 102) = 3.47, p=0.035) and it could predict 4.7% of intelligence. Our results suggest that Met/Met genotype has a positive effect on intelligence but not on creative ability. However, we found no significant interaction between gender and COMT genotype to intelligence. |
| 收录类别 | EI |
| 学科主题 | 发展心理学 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/8828]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 推荐引用方式 GB/T 7714 | Shi JN. Association between creativity and COMT genotype[C]. 见:2010 4th International Conference on Bioinformatics and Biomedical Engineering. Chengdu, China. 2010. |
入库方式： OAI收割
来源：心理研究所
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