Role of Zebrafish Lbx2 in Embryonic Lateral Line Development
文献类型：期刊论文
| 作者 | Chen, Xiaowen1,2; Lou, Qiyong1,2; He, Jiangyan1,2; Yin, Zhan1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011-12-22 |
| 卷号 | 6期号:12页码:e29515 |
| 关键词 | TRANSCRIPTION FACTOR LBX1 MUSCLE PRECURSOR CELLS DORSAL SPINAL-CORD GENE LBX1 TRANSMITTER PHENOTYPES TISSUE MIGRATION DANIO-RERIO HAIR-CELLS IN-VIVO EXPRESSION |
| ISSN号 | 1932-6203 |
| 通讯作者 | Chen, XW (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China. |
| 中文摘要 | Background: The zebrafish ladybird homeobox homologous gene 2 (lbx2) has been suggested to play a key role in the regulation of hypaxial myogenic precursor cell migration. Unlike their lbx counterparts in mammals, the function of teleost lbx genes beyond myogenesis during embryonic development remains unexplored. Principal Findings: Abrogation of lbx2 function using a specific independent morpholino oligonucleotide (MO) or truncated lbx2 mRNA with an engrailed domain deletion (lbx2(eh-)) resulted in defective formation of the zebrafish posterior lateral line (PLL). Migration of the PLL primordium was altered and accompanied by increased cell death in the primordium of lbx2-MO-injected embryos. A decreased number of muscle pioneer cells and impaired expression pattern of sdf1a in the horizontal myoseptum was observed in lbx2 morphants. Significance: Injection of lbx2 MO or lbx2(eh-) mRNA resulted in defective PPL formation and altered sdf1a expression, confirming an important function for lbx2 in sdf1a-dependent migration. In addition, the disassociation of PPL nerve extension with PLL primordial migration in some lbx2 morphants suggests that pathfinding of the PLL primordium and the lateral line nerve may be regulated independently. |
| 英文摘要 | Background: The zebrafish ladybird homeobox homologous gene 2 (lbx2) has been suggested to play a key role in the regulation of hypaxial myogenic precursor cell migration. Unlike their lbx counterparts in mammals, the function of teleost lbx genes beyond myogenesis during embryonic development remains unexplored. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | TRANSCRIPTION FACTOR LBX1 ; MUSCLE PRECURSOR CELLS ; DORSAL SPINAL-CORD ; GENE LBX1 ; TRANSMITTER PHENOTYPES ; TISSUE MIGRATION ; DANIO-RERIO ; HAIR-CELLS ; IN-VIVO ; EXPRESSION |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] |
| 语种 | 英语 |
| WOS记录号 | WOS:000299684700063 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/17025]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xiaowen,Lou, Qiyong,He, Jiangyan,et al. Role of Zebrafish Lbx2 in Embryonic Lateral Line Development[J]. PLOS ONE,2011,6(12):e29515. |
| APA | Chen, Xiaowen,Lou, Qiyong,He, Jiangyan,&Yin, Zhan.(2011).Role of Zebrafish Lbx2 in Embryonic Lateral Line Development.PLOS ONE,6(12),e29515. |
| MLA | Chen, Xiaowen,et al."Role of Zebrafish Lbx2 in Embryonic Lateral Line Development".PLOS ONE 6.12(2011):e29515. |
入库方式： OAI收割
来源：水生生物研究所
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