Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA
文献类型：期刊论文
| 作者 | Zhao, Qin Ping1,2; Sen Jiang, Ming1; Dong, Hui Fen1; Nie, Pin2 |
| 刊名 | PLOS NEGLECTED TROPICAL DISEASES
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 6期号:2页码:e1503 |
| 关键词 | ONCOMELANIA-HUPENSIS GASTROPODA POPULATION GENETIC-STRUCTURE MOLECULAR PHYLOGENY SEQUENCE ALIGNMENT ECOLOGY HOST POLYMORPHISM POMATIOPSIDAE EPIDEMIOLOGY DIVERSITY |
| ISSN号 | 1935-2727 |
| 通讯作者 | Zhao, QP (reprint author), Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China. |
| 中文摘要 | Background: Schistosoma japonicum still causes severe parasitic disease in mainland China, but mainly in areas along the Yangtze River. However, the genetic diversity in populations of S. japonicum has not been well understood across its geographical distribution, and such data may provide insights into the epidemiology and possible control strategies for schistosomiasis. Methodology/Principal Findings: In this study infected Oncomelania snails were collected from areas in the middle and lower (ML) reaches of the Yangtze River, including Hubei, Hunan, Anhui, Jiangxi and Jiangsu provinces, and in the upper reaches of the river, including Sichuan and Yunnan provinces in southwest (SW) China. The adult parasites obtained from experimentally infected mice using isolated cercariae were sequenced individually for several fragments of mitochondrial regions, including Cytb-ND4L-ND4, 16S-12S and ND1. Populations in the ML reaches exhibited a relatively high level of diversity in nucleotides and haplotypes, whereas a low level was observed for populations in the SW, using either each single fragment or the combined sequence of the three fragments. Pairwise analyses of F-statistics (Fst) revealed a significant genetic difference between populations in the ML reaches and those in the SW, with limited gene flow and no shared haplotypes in between. It is rather obvious that genetic diversity in the populations of S. japonicum was significantly correlated with the geographical distance, and the geographical separation/isolation was considered to be the major factor accounting for the observed difference between populations in the ML reaches and those in the SW in China. Conclusions: S. japonicum in mainland China exhibits a high degree of genetic diversity, with a similar pattern of genetic diversity as observed in the intermediate host snails in the same region in China. |
| 英文摘要 | Background: Schistosoma japonicum still causes severe parasitic disease in mainland China, but mainly in areas along the Yangtze River. However, the genetic diversity in populations of S. japonicum has not been well understood across its geographical distribution, and such data may provide insights into the epidemiology and possible control strategies for schistosomiasis. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Infectious Diseases ; Parasitology ; Tropical Medicine |
| 研究领域[WOS] | Infectious Diseases ; Parasitology ; Tropical Medicine |
| 关键词[WOS] | ONCOMELANIA-HUPENSIS GASTROPODA ; POPULATION GENETIC-STRUCTURE ; MOLECULAR PHYLOGENY ; SEQUENCE ALIGNMENT ; ECOLOGY ; HOST ; POLYMORPHISM ; POMATIOPSIDAE ; EPIDEMIOLOGY ; DIVERSITY |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] |
| 语种 | 英语 |
| WOS记录号 | WOS:000300949200017 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16951]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China 2.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qin Ping,Sen Jiang, Ming,Dong, Hui Fen,et al. Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA[J]. PLOS NEGLECTED TROPICAL DISEASES,2012,6(2):e1503. |
| APA | Zhao, Qin Ping,Sen Jiang, Ming,Dong, Hui Fen,&Nie, Pin.(2012).Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA.PLOS NEGLECTED TROPICAL DISEASES,6(2),e1503. |
| MLA | Zhao, Qin Ping,et al."Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA".PLOS NEGLECTED TROPICAL DISEASES 6.2(2012):e1503. |
入库方式： OAI收割
来源：水生生物研究所
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