[Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection
文献类型：期刊论文
| 作者 | Yu, JF（于俊锋） ; Yin, DZ（尹端沚） ; Min, XF ; Guo, ZL ; Zhang, J ; Wang, YX ; Knapp, FF |
| 刊名 | NUCLEAR MEDICINE AND BIOLOGY
 |
| 出版日期 | 1999 |
| 卷号 | 26期号:5页码:573 |
| ISSN号 | 0969-8051 |
| 英文摘要 | Intralesional therapy has been shown to be an effective treatment for tumors. In this study, the suitability of [Re-188]rhenium sulfide suspension for tumor treatment following intra-tumor injection was evaluated. The [Re-188]rhenium sulfide suspension was radiolabeled with Re-188 with a radiochemical yield of more than 96%. In vitro stability studies revealed that more than 99% of the Re-188 remained in sulfide form over a 3-day period. After ultrasonication for 5 or 10 min, the main particle size was 1-5 mu m. Two [Re-188]rhenium sulfide suspensions ultrasonicated for 5 and 10 min, respectively, were injected into separate group of tumor-bearing mice that were killed after specified times to compare the retention of Re-188 in tumors and the leakage to different organs by periods and organs removed to gamma counting. The mean retention percentages of Re-188 in tumors injected with suspension ultrasonicated for 5 (or 10) min were as follows: 1 h, 90.5 +/- 7.7% (83.1 +/- 13.7%); 24 h, 92.2 +/- 8.6% (83.9 +/- 9.8%); 48 h, 88.3 +/- 10.9% (80.2 +/- 3.8%); and 72 h, 91.5 +/- 7.6% (78.8 +/- 3.0%). Tumor-inhibiting ratio was 96.5%. These results demonstrated that [Re-188]rhenium sulfide suspension is an effective radiopharmaceutical for tumor treatment by intralesional therapy. (C) 1999 Elsevier Science Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000081586800012 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9841]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Yu, JF,Yin, DZ,Min, XF,et al. [Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection[J]. NUCLEAR MEDICINE AND BIOLOGY,1999,26(5):573. |
| APA | Yu, JF.,Yin, DZ.,Min, XF.,Guo, ZL.,Zhang, J.,...&Knapp, FF.(1999).[Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection.NUCLEAR MEDICINE AND BIOLOGY,26(5),573. |
| MLA | Yu, JF,et al."[Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection".NUCLEAR MEDICINE AND BIOLOGY 26.5(1999):573. |
入库方式： OAI收割
来源：上海应用物理研究所
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