Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)
文献类型：期刊论文
| 作者 | Li, QN（李晴暖） ; Xiu, Y ; Zhang, XD（张晓东） ; Liu, RL（刘瑞丽） ; Du, QQ ; Sun, AG ; Chen, SL ; Li, WX（李文新） |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2001 |
| 卷号 | 46期号:19页码:1615 |
| ISSN号 | 1001-6538 |
| 英文摘要 | The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C-60 derivatives as drugs or drug carriers, a simple water-soluble derivative C-60(OH)(x)(O)(y) was labeled with Te-99m. A gamma -counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to rind out to what extent the C60 itself determines the biodistribution of derivatives. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000172324000010 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9884]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Li, QN,Xiu, Y,Zhang, XD,et al. Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)[J]. CHINESE SCIENCE BULLETIN,2001,46(19):1615. |
| APA | Li, QN.,Xiu, Y.,Zhang, XD.,Liu, RL.,Du, QQ.,...&Li, WX.(2001).Biodistribution of fullerene derivative C-60(OH)(x)(O)(y).CHINESE SCIENCE BULLETIN,46(19),1615. |
| MLA | Li, QN,et al."Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)".CHINESE SCIENCE BULLETIN 46.19(2001):1615. |
入库方式： OAI收割
来源：上海应用物理研究所
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