EXAFS study on the local atomic structures around iron in glycosylated haemoglobin
文献类型：期刊论文
| 作者 | Wu, ZH ; Benfield, RE ; Wang, YS（王荫松） ; Guo, L ; Tan, MG（谈明光） ; Zhang, HD ; Ge, YX ; Grandjean, D |
| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2001 |
| 卷号 | 46期号:3页码:N71 |
| ISSN号 | 0031-9155 |
| 英文摘要 | Samples with 5.1%, 9.8% and 15.3% HbA1c were extracted from normal subjects and patients with slight and serious diabetes respectively. Extended x-ray absorption fine structure spectra of Fe K absorption were collected at the EXAFS experimental station of the Beijing Synchrotron Radiation Facility. The step-by-step fluorescent mode was employed with a count time of 10 s per point. Several independent scans were averaged to eliminate the statistical noise. Reference backscattering amplitudes and phaseshifts were calculated using the curve wave theory (FEFF code) of EXAFS. Apart from the nitrogen neighbours around the central iron atom, oxygen neighbours are also found. The Fe-N bond length increases by about 0.02 Angstrom for the sample with 15.3% HbA1c compared with the others, but the Fe-O bond length is almost unchanged. With increasing of HbA1c concentration, the content of Hb increases and the content of HbO(2) decreases. This demonstrates that the glycosylation of haemoglobin will decrease its ability to carry oxygen. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000167520400024 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/9966]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Wu, ZH,Benfield, RE,Wang, YS,et al. EXAFS study on the local atomic structures around iron in glycosylated haemoglobin[J]. PHYSICS IN MEDICINE AND BIOLOGY,2001,46(3):N71. |
| APA | Wu, ZH.,Benfield, RE.,Wang, YS.,Guo, L.,Tan, MG.,...&Grandjean, D.(2001).EXAFS study on the local atomic structures around iron in glycosylated haemoglobin.PHYSICS IN MEDICINE AND BIOLOGY,46(3),N71. |
| MLA | Wu, ZH,et al."EXAFS study on the local atomic structures around iron in glycosylated haemoglobin".PHYSICS IN MEDICINE AND BIOLOGY 46.3(2001):N71. |
入库方式： OAI收割
来源：上海应用物理研究所
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