Intratumoral injection with [Re-188]rhenium sulfide suspension for treatment of transplanted human liver carcinoma in nude mice
文献类型：期刊论文
| 作者 | Yu, JF（于俊锋） ; Zhang, RP ; Dai, XL ; Min, XF（闵小锋） ; Xu, JY ; Hu, WQ ; Yin, DZ（尹端祉） ; Zhou, W（周伟） ; Xie, H ; Wang, YX（汪勇先） ; Knapp, FF |
| 刊名 | NUCLEAR MEDICINE AND BIOLOGY
 |
| 出版日期 | 2000 |
| 卷号 | 27期号:4页码:347 |
| ISSN号 | 0969-8051 |
| 英文摘要 | Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. Direct intratumoral injection of nonremovable radioactive material has been widely studied because it could deliver high doses of radiation to target sites and minimize radiation leakage to non-target organs or tissues. Thirty nude mice bearing SMMC 7721 human liver carcinoma were used for the biodistribution study after intratumoral injection of [Re-188]rhenium sulfide suspension or sodium [Re-188]perrhenate solution. Another 30 tumor-bearing mice were divided into six groups, four groups of which were treated with a 0.1 ml [Re-188]rhenium sulfide suspension at doses of 3.7, 7.4, 18.5, 29.6 MBq by a single intratumoral injection. For control studies, to study the tumor inhibiting ratio, the remaining two groups were injected with nonradioactive rhenium sulfide suspension and Hanks' balanced salt solution, respectively. The injections were repeated 6 days later, The retention percentages of radioactivity (%ID) in tumors injected with [Re-188]rhenium sulfide suspension were 90.96 + 6.63%, 86.09 +/- 22.58% and 87.62 +/- 13.97% at 1, 24 and 48 h, respectively. Tumor inhibition ratios are as high as 89% when the outer space of tumor (0.5-0.6 cm from center) received about 507.6 Gy doses. Intratumoral injection of [Re-188]rhenium sulfide suspension results in high tumor retention indicating this approach has strong potential for the treatment of hepatic carcinoma, NUCL MED BIOL 27;4:347-352, 2000. (C) 2000 Elsevier Science Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000088823900004 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/10007]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Yu, JF,Zhang, RP,Dai, XL,et al. Intratumoral injection with [Re-188]rhenium sulfide suspension for treatment of transplanted human liver carcinoma in nude mice[J]. NUCLEAR MEDICINE AND BIOLOGY,2000,27(4):347. |
| APA | Yu, JF.,Zhang, RP.,Dai, XL.,Min, XF.,Xu, JY.,...&Knapp, FF.(2000).Intratumoral injection with [Re-188]rhenium sulfide suspension for treatment of transplanted human liver carcinoma in nude mice.NUCLEAR MEDICINE AND BIOLOGY,27(4),347. |
| MLA | Yu, JF,et al."Intratumoral injection with [Re-188]rhenium sulfide suspension for treatment of transplanted human liver carcinoma in nude mice".NUCLEAR MEDICINE AND BIOLOGY 27.4(2000):347. |
入库方式： OAI收割
来源：上海应用物理研究所
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