Preparation of (Re-188) Re-AEDP and its biodistribution studies
文献类型：期刊论文
| 作者 | Li, QN（李晴暖） ; Zhang, XD（张晓东） ; Sheng, R ; Li, WX（李文新） |
| 刊名 | APPLIED RADIATION AND ISOTOPES
 |
| 出版日期 | 2000 |
| 卷号 | 53期号:6页码:993 |
| ISSN号 | 0969-8043 |
| 英文摘要 | The synthesis of the Re (V) complex and preparation of Re-188-AEDP are described using Re-188 which was obtained from the alumina-based W-188/Re-188 generator. Dependence of the radiolabeling yields of Re-188-AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of Re-188-AEDP were 92-93% for carrier-free Re-188 and 95-98% for carrier-added Re-188. The stability of Re-188-AEDP at pH approximate to 6 was studied and it is found that the carrier has a significant effect on the stability of Re-188-AEDP. The biodistribution of carrier-free and carrier-added Re-188-labelled compounds in rats was also measured. The results show that Re-188 (carrier-added)-AEDP is a potential bone palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000089793200005 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/10114]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Li, QN,Zhang, XD,Sheng, R,et al. Preparation of (Re-188) Re-AEDP and its biodistribution studies[J]. APPLIED RADIATION AND ISOTOPES,2000,53(6):993. |
| APA | Li, QN,Zhang, XD,Sheng, R,&Li, WX.(2000).Preparation of (Re-188) Re-AEDP and its biodistribution studies.APPLIED RADIATION AND ISOTOPES,53(6),993. |
| MLA | Li, QN,et al."Preparation of (Re-188) Re-AEDP and its biodistribution studies".APPLIED RADIATION AND ISOTOPES 53.6(2000):993. |
入库方式： OAI收割
来源：上海应用物理研究所
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