Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice
文献类型：期刊论文
| 作者 | Yu, JF（于俊锋） ; Yin, DZ（尹端沚） ; Min, XF（闵小锋） ; Guo, ZL ; Zhang, J ; Wang, YX（汪勇先） ; Knapp, FF |
| 刊名 | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
 |
| 出版日期 | 1999 |
| 卷号 | 42期号:3页码:233 |
| ISSN号 | 0362-4803 |
| 英文摘要 | [Re-188]Rhenium sulfide suspension was prepared by the reaction of Na2S2O3 and KReO4 containing (NaReO4)-Re-188 in acid solution and assessed for its applicability in tumor treatment by the techniques of radioisotope interventional therapy. The reaction conditions such as the concentration ratio of Na2S2O3, to KReO4, heating time, ultrasonic time were optimized. The radiochemical yield of [Re-188]Rhenium sulfide suspension is more than 96% and in vitro stability studies demonstrated that more than 99% of the 188Re remained in sulfide form over a 72hrs period. The main particle size after various ultrasonic times is 1-5 mu m. [Re-188]Rhenium sulfide suspension was injected into tumors and the tumor-bearing mice were killed after some time to determine the retention of Re-188 in tumor and the leakage to different organs by gamma counter. The mean retention percentages of Re-188 in tumors were 83.08 +/- 13.71%, 83.92 +/- 9.79%, 80.23 +/- 3.82% and 78.75 +/- 3.02% at Ih, 24, 48 and 72hrs respectively. After 72hrs the highest activity outside the tumors was in the liver, spleen and the kidneys. Our preliminary results indicated that [Re-188]Rhenium sulfide suspension may be an effective radiopharmaceutical for tumor treatment by the techniques of radioisotope interventional therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000078818900004 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/10115]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Yu, JF,Yin, DZ,Min, XF,et al. Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,1999,42(3):233. |
| APA | Yu, JF.,Yin, DZ.,Min, XF.,Guo, ZL.,Zhang, J.,...&Knapp, FF.(1999).Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,42(3),233. |
| MLA | Yu, JF,et al."Preparation of [Re-188]Rhenium sulfide suspension and its biodistribution following intra-tumor injection in mice".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 42.3(1999):233. |
入库方式： OAI收割
来源：上海应用物理研究所
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