Radiolabeling of magnetic targeted carriers (MTC) with indium-111
文献类型：期刊论文
| 作者 | Hafeli, UO ; Yu, JF（于俊锋） ; Farudi, F ; Li, YH ; Tapolsky, G |
| 刊名 | NUCLEAR MEDICINE AND BIOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 30期号:7页码:761 |
| ISSN号 | 0969-8051 |
| 英文摘要 | Magnetic targeted carriers (MTC) are magnetically susceptible microparticles that can be physically targeted to a specific site. MTC were radiolabeled with In-111 using three different methods. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The reaction parameters studied were chelation agent, chelation time, temperature, radiolabeling time, solvent, and molar ratios. A 97.7 +/- 0.9% binding efficiency and plasma stability of 92.6 +/- 0.1% over 7 days were achieved when 2-p-aminobenzyl-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (ABz-DOTA) was used as the chelating agent. A preliminary animal biodistribution study confirmed the binding stability. The labeling of the MTC with the diagnostic isotope In-111 was undertaken to allow for quantitative imaging and dosimetry prior to therapy with Y-90 radiolabeled MTC. (C) 2003 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000185746200011 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/10139]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Hafeli, UO,Yu, JF,Farudi, F,et al. Radiolabeling of magnetic targeted carriers (MTC) with indium-111[J]. NUCLEAR MEDICINE AND BIOLOGY,2003,30(7):761. |
| APA | Hafeli, UO,Yu, JF,Farudi, F,Li, YH,&Tapolsky, G.(2003).Radiolabeling of magnetic targeted carriers (MTC) with indium-111.NUCLEAR MEDICINE AND BIOLOGY,30(7),761. |
| MLA | Hafeli, UO,et al."Radiolabeling of magnetic targeted carriers (MTC) with indium-111".NUCLEAR MEDICINE AND BIOLOGY 30.7(2003):761. |
入库方式： OAI收割
来源：上海应用物理研究所
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