Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study
文献类型：期刊论文
| 作者 | Lu, CY（陆长元） ; Han, ZH（韩镇辉） ; Lin, WZ（林维真） ; Wang, WF（王文锋） ; Yao, SD（姚思德） ; Lin, NY（林念芸） |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2000 |
| 卷号 | 58期号:1页码:29 |
| ISSN号 | 0567-7351 |
| 英文摘要 | Time - resolved pulse radiolysis has been used to study the reactions of etoposide (VP 16) with N-3(.) , (SCN)2(. -), e(aq)(-) in aqueous solution. The absorption spectra of reaction products were investigated, and a series of rate constants were determined to be 2 . 7 x 10(9), 3 . 2 x 10(9), 2 . 5 x 10(8) dm(3) . mol (- 1) . s (- 1) for reactions of e(aq)(-) N-3(.) , (SCN)(2)(. -) with etoposide, respectively. Using laser flash photolysis techniques, it is demonstrated that VP16 in aqueous solution is ionized by 248 nm photon to give hydrated electron and neutral radical resulting from rapid deprotonation of radical cation of etoposide. The pK value of VP16 is found to be 10 . 6, and the rate constants for reaction of VP16 with SO4. - is 2 . 8 x 10(9) dm(3) . mol (- 1). s (- 1). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000084780600006 |
| 公开日期 | 2012-09-25 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/10145]  |
| 专题 | 上海应用物理研究所_中科院上海原子核所2003年前 |
| 推荐引用方式 GB/T 7714 | Lu, CY,Han, ZH,Lin, WZ,et al. Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study[J]. ACTA CHIMICA SINICA,2000,58(1):29. |
| APA | Lu, CY,Han, ZH,Lin, WZ,Wang, WF,Yao, SD,&Lin, NY.(2000).Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study.ACTA CHIMICA SINICA,58(1),29. |
| MLA | Lu, CY,et al."Redox reactions of etoposide in aqueous solution - A pulse radiolysis and laser flash photolysis study".ACTA CHIMICA SINICA 58.1(2000):29. |
入库方式： OAI收割
来源：上海应用物理研究所
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