Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells
文献类型：期刊论文
| 作者 | Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai |
| 刊名 | FOOD AND AGRICULTURAL IMMUNOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 21期号:1页码:57-64 |
| 关键词 | anti-inflammatory activity lansai C and D NF-kappa B RAW 264 7 cells STAT-1 NITRIC-OXIDE SYNTHASE STREPTOMYCES SP SUC1 SELECTIVE-INHIBITION INOS EXPRESSION MACROPHAGES GAMMA |
| ISSN号 | 0954-0105 |
| 通讯作者 | Taechowisan, T (reprint author), Silpakorn Univ, Dept Microbiol, Fac Sci, Nakhon Pathom 73000, Thailand. tthongch@su.ac.th |
| 英文摘要 | In inflammation, proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we investigated the effects of lansai C and D on NO production in lipopolysaccharide-induced RAW 264.7 cells, and evaluated the mechanisms of action of the compounds. Lansai C and D inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. These compounds inhibited the activation of nuclear factor-B, which is a significant transcription factor for iNOS and also inhibited the activation of the signal transducer and activator of transcription-1, another important transcription factor for iNOS. The present study characterises the effects and mechanisms of lansais on iNOS expression and NO production in activated macrophages. The results explain the pharmacological efficacy of lansais as anti-inflammatory compounds. |
| 学科主题 | Chemistry, Applied; Food Science & Technology; Immunology; Toxicology |
| 收录类别 | SCI |
| 资助信息 | Thailand Research Fund[MRG5180173]; Faculty of Science, Silpakorn University |
| 语种 | 英语 |
| 公开日期 | 2012-10-12 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/15376]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,et al. Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2010,21(1):57-64. |
| APA | Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,&Liu, Jikai.(2010).Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells.FOOD AND AGRICULTURAL IMMUNOLOGY,21(1),57-64. |
| MLA | Taechowisan, Thongchai,et al."Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells".FOOD AND AGRICULTURAL IMMUNOLOGY 21.1(2010):57-64. |
入库方式： OAI收割
来源：昆明植物研究所
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