Identification of nigral dopaminergic neuron-enriched genes in adult rats
文献类型：期刊论文
| 作者 | Zhou, Jiawei
|
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:2页码:313-326 |
| 关键词 | Substantia nigra Dopaminergic neurons Microarray Affymetrix Gene expression DIFFERENTIAL EXPRESSION HEMIPARKINSONIAN RATS PARKINSONS-DISEASE SUBSTANTIA-NIGRA GDNF-FAMILY IN-VITRO DEGENERATION PROTEIN 6-HYDROXYDOPAMINE VULNERABILITY |
| ISSN号 | 0197-4580 |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurobiol, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,jwzhou@ion.ac.cn |
| 英文摘要 | Dopaminergic (DA) neurons in the substantia nigra play crucial roles in movement control and other physiological activities. Degeneration of these neurons is closely associated with Parkinson's disease. However, the molecular identity of nigral DA neurons is not fully understood. To identify nigral DA neuron-enriched genes, we used microarrays to compare the genome-wide gene expression profiles in 6-hydroxydopamine-lesioned, and control, substantia nigra. We identified a total of 88 unique differentially expressed gene transcripts. The spatial expression patterns of a set of these genes, including Slc10a4, Rit2, F2r, Snx10 and Slc24a3, were validated by in situ hybridization. It was revealed that their expression was highly specific in the substantia nigra. Thus we identified a set of genes that are highly expressed in nigral DA neurons, and may be involved in the maintenance and survival of nigral DA neurons in the adult rat brain. Our study also provides a general approach for profiling cell type-specific gene expression in the mature mammalian brain. (C) 2009 Elsevier Inc. All rights reserved. |
| 学科主题 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences[07DJ14005]; "863" High-Tech Research and Development of China[2006AA02Z184, 2006AA02A114]; Natural Science Foundation of China[30525041, 30621130075, 30623003]; State Key Program for Basic Research of China[2006CB500704] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1556]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_基底神经节的发育与退行性疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Jiawei. Identification of nigral dopaminergic neuron-enriched genes in adult rats[J]. NEUROBIOLOGY OF AGING,2011,32(2):313-326. |
| APA | Zhou, Jiawei.(2011).Identification of nigral dopaminergic neuron-enriched genes in adult rats.NEUROBIOLOGY OF AGING,32(2),313-326. |
| MLA | Zhou, Jiawei."Identification of nigral dopaminergic neuron-enriched genes in adult rats".NEUROBIOLOGY OF AGING 32.2(2011):313-326. |
入库方式： OAI收割
来源：上海神经科学研究所
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