Expression of Ventral Diencephalon-Enriched Genes in Zebrafish
文献类型：期刊论文
| 作者 | Zhou, Jiawei
|
| 刊名 | DEVELOPMENTAL DYNAMICS
 |
| 出版日期 | 2010 |
| 卷号 | 239期号:12页码:3368-3379 |
| 关键词 | dopaminergic neuron diencephalon Id3 maturation MIDBRAIN DOPAMINERGIC-NEURONS TRANSCRIPTION FACTOR KLF7 CELL FATE NURR1 SURVIVAL ID3 DIFFERENTIATION NEUROGENESIS PROTEIN SYSTEM |
| ISSN号 | 1058-8388 |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,jwzhou@ion.ac.cn |
| 英文摘要 | Dopaminergic (DA) neurons in the vertebrate di- and mesencephalon play essential roles in movement control, endocrine modulation and many other important physiological activities. To identify genes that may regulate the specification and differentiation of diencephalic DA neurons in zebrafish, the spatial and temporal expression pattern of a set of genes was investigated. In situ hybridization analysis revealed that expression of DNA binding inhibitor 3 (Id3), early B cell factor 2 (Ebf2), Ebf3, Iroquois related homeobox 1 (Irx1), Kruppel-like factor 7 (Klf7), mab-21-like 1 (Mab21l1), fatty acid binding protein 7 (Fabp7) and stathmin-like 4 (Stmn4), were enriched in the diencephalon of zebrafish. Among these genes, Id3 was expressed specifically in a subset of DA neurons in the ventral diencephalon, with co-expression of neurogenin1 (Ngn1). Alteration of expression levels of Id3 inhibited maturation of developing DA neurons. Taken together, our study provides genetic characteristics of DA neurons in the diencephalon of zebrafish. Developmental Dynamics 239:3368-3379, 2010. (C) 2010 Wiley-Liss, Inc. |
| 学科主题 | Anatomy & Morphology ; Developmental Biology |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences, Chinese Ministry of Science Technology[2006AA02A114]; Natural Science Foundation of China[30525041, 30721004]; State Key Program for Basic Research of China[2006CB500704, 2007CB947100] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1563]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_基底神经节的发育与退行性疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Jiawei. Expression of Ventral Diencephalon-Enriched Genes in Zebrafish[J]. DEVELOPMENTAL DYNAMICS,2010,239(12):3368-3379. |
| APA | Zhou, Jiawei.(2010).Expression of Ventral Diencephalon-Enriched Genes in Zebrafish.DEVELOPMENTAL DYNAMICS,239(12),3368-3379. |
| MLA | Zhou, Jiawei."Expression of Ventral Diencephalon-Enriched Genes in Zebrafish".DEVELOPMENTAL DYNAMICS 239.12(2010):3368-3379. |
入库方式： OAI收割
来源：上海神经科学研究所
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