Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo
文献类型：期刊论文
| 作者 | Zhou, Jiawei
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2009 |
| 卷号 | 29期号:16页码:5170-5182 |
| 关键词 | RADIAL GLIA CELLS RAT DIFFERENTIATION SPECIFICATION NEUROGENIN-2 EXPRESSION PROJECTION MIGRATION STRIATUM |
| ISSN号 | 0270-6474 |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,jwzhou@ion.ac.cn |
| 英文摘要 | Mesodiencephalic dopaminergic (mDA) neurons are critical for movement control and other physiological activities. However, the molecular mechanisms underlying their development are poorly understood. We aimed to establish the expression profiles of genes involved in this process and unravel genetic programs that control late development of mDA neurons. We compared genome-wide gene expression profiles of developing mouse ventral mesencephalon (VM) using microarrays. We identified a set of genes that show spatially and temporally restricted expression in the VM in an Ngn2 ( neurogenin 2)-dependent manner and are potentially important for mDA neuron development. Functional analysis on mice lacking the VM-specific gene early B-cell factor 1 (Ebf1) revealed that Ebf1 is essential for the terminal migration of mDA neurons in the substantia nigra pars compacta. Thus, we identified a set of VM-enriched genes that are important for mDA neuron development. Our analysis also provides a genetic framework for further investigation of the molecular mechanisms mediating mDA neuron development. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | State Key Program for Basic Research of China[2006CB500704, 2007CB947100]; "863" Research Program[2006AA02A114]; Natural Science Foundation of China[30525041, 30623003, 30621130075]; Shanghai Metropolitan Fund for Research and Development[07DJ14005]; Institute of Biochemistry and Cell Biology, Shanghai, China |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1663]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_基底神经节的发育与退行性疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhou, Jiawei. Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo[J]. JOURNAL OF NEUROSCIENCE,2009,29(16):5170-5182. |
| APA | Zhou, Jiawei.(2009).Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo.JOURNAL OF NEUROSCIENCE,29(16),5170-5182. |
| MLA | Zhou, Jiawei."Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo".JOURNAL OF NEUROSCIENCE 29.16(2009):5170-5182. |
入库方式： OAI收割
来源：上海神经科学研究所
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